Fig. 11.

Ferrostatin-1 (Fer-1) attenuates erastin-induced ferroptosis in HO-1^+/+ and HO-1^−/− PTCs. Cell viability in HO-1^+/+ (A) and HO-1^−/− (B) PTCs treated with either 0.1 or 1 μM erastin with or without Fer-1 (0.1 or 1 μM) for 16 h. C: representative Western blot showing cells treated with erastin in the presence or absence of Fer-1. Data represented as means ± SE of four to six independent experiments with four to eight replicates in each experiment; *P < 0.05 and **P < 0.01 compared with vehicle-treated cells; #P < 0.01 compared with erastin-only treatments.