Fig. 2. Three-month seizure outcomes and occurrence of adverse events for different maximum doses of perampanel. A: The maximum doses were 2 and 4 mg in 7 patients. Two patients achieved seizure freedom when taking perampanel at the relatively low dose of 4 mg. The maximum doses were 6, 8, and 10 mg in more than two-thirds (56 of 81 patients) of patients. The rates of responders and seizure freedom were high for doses between 6 and 10 mg. The perampanel dose was increased to 12 mg when their seizures persisted, and no serious adverse events occurred. However, the rates of responders and seizure freedom were significantly low at a dose of 12 mg. B: Five patients stopped taking perampanel at low doses (e.g., 2 or 4 mg) due to adverse events. Only one patient stopped taking perampanel at 12 mg. Two patients who stopped at a dose of 2 mg experienced severe dizziness, and three patients who stopped at a dose of 4 mg reported experiencing multiple side effects including gait disturbance, dizziness, and aggressive behavior.