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HNE inhibitory activity of benzoisoxazolone derivatives 10a–c.
 | ||
|---|---|---|
| Comp. | R1 | IC50 (µM)a |
| 10a | C2H5 | 25.1 ± 3.6 |
| 10b | C4H9 | NA |
| 10c | m-CH3-Ph | 0.638 ± 0.121 |
| Sivelestat | 0.044 ± 0.011 | |
IC50 values are presented as the mean ± SD of three independent experiments.
NA: no inhibitory activity was found at the highest concentration of compound tested (50 µM).
