Time profiles of cortisol (A), PER/CRY protein (B), Bmal1 mRNA (C), BMAL1 protein (D), CLOCK/BMAL1 complex (E), and Pck1/G6pc mRNA (F) are shown under nominal condition (black lines), Bmal1 knockout condition (gray dotted-dashed lines), and Clock knockout condition (gray dashed lines).