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Time profiles of cortisol (A), PER/CRY protein (B), CLOCK/BMAL1 complex (C), nuclear (N) PGC-1α (D), and Pck1/G6pc mRNA (E) are shown under nominal condition and Clock knockout (KO) condition. The rest of the profiles show Clock knockout condition adjusted by correction factor for certain parameters: kg1, k1i, and k4b. The light and feeding schedule are synchronized for all profiles. WT, wild-type.
