Fig. 2.

Effects of intermittent parathyroid hormone (PTH) administration and the marrow microenvironment on endothelium-dependent vasodilation of the femoral principal nutrient artery to ACh in young and old rats. A: no differences in vasodilation were observed between Young Control (CON) and Young PTH. Incubation with marrow reduced vasodilation in Young CON+Marrow and Young PTH+Marrow. B: vasodilation in Old PTH tended to be higher than in Old CON and was higher than in Old CON+Marrow. Vasodilator responses differed between Old PTH+Marrow and Old CON+Marrow. Data were analyzed by repeated-measures ANOVAs with pairwise comparisons. Values are means ± SE. PRE, before ACh administration. ^aP < 0.050 vs. Young CON+Marrow; ^bP < 0.050 vs. Young PTH+Marrow; ^cP = 0.060 vs. Old CON; ^dP < 0.050 vs. Old CON+Marrow.