Table 5.

Cytokine concentration in the absence and presence of marrow following intermittent PTH 1–34 administration in young and old rats

	CON	CON+Marrow	PTH	PTH+Marrow
Young
n	3	3	3	3
Proinflammatory cytokines, pg/ml
IL-1α	1.00 ± 0.29	3.45 ± 0.68	0.68 ± 0.26	8.43 ± 5.81
IL-6	4.18 ± 0.08	4.66 ± 0.39	3.60 ± 0.65	22.25 ± 11.23
RANTES	15.04 ± 0.74	20.00 ± 0.51	15.60 ± 0.65	27.20 ± 5.34
M-CSF	2.07 ± 0.09	2.11 ± 0.02	1.75 ± 0.15	5.23 ± 2.04
MIP-1α	2.81 ± 0.09	3.08 ± 0.03	2.81 ± 0.09	5.09 ± 1.93
MIP-3α	18.99 ± 0.43	19.83 ± 0.50	18.91 ± 1.15	29.40 ± 10.40
VEGF	0.63 ± 0.12	1.31 ± 0.36	0.96 ± 0.67	5.32 ± 4.14
Anti-inflammatory cytokines, pg/ml
IL-4	0.30 ± 0.03	0.58 ± 0.03	0.31 ± 0.03	2.61 ± 1.28
IL-13	0.43 ± 0.12	0.48 ± 0.21	0.44 ± 0.33	12.56 ± 12.15
Old
n	3	3	3	3
Proinflammatory cytokines, pg/ml
IL-1α	0.67 ± 0.27	1.91 ± 0.56	0.49 ± 0.07	2.49 ± 0.95
IL-6	2.11 ± 0.11	1.77 ± 0.31	2.07 ± 0.41	4.41 ± 1.49
RANTES	13.35 ± 0.59	89.59 ± 26.50	12.27 ± 0.59	82.19 ± 38.53
M-CSF	1.59 ± 0.14	1.80 ± 0.02	1.42 ± 0.11	1.99 ± 0.17
MIP-1α	2.85 ± 0.04	8.77 ± 5.51	2.65 ± 0.03	4.29 ± 0.27
MIP-3α	17.76 ± 0.58	19.92 ± 1.24	16.96 ± 0.21	20.30 ± 1.04
VEGF	0.32 ± 0.05	1.94 ± 0.75	0.24 ± 0.00*	2.49 ± 0.35
Anti-inflammatory cytokines, pg/ml
IL-4	0.26 ± 0.01	0.32 ± 0.01	0.19 ± 0.04	0.54 ± 0.16
IL-13	0.21 ± 0.03	0.24 ± 0.10	0.11 ± 0.00*	1.90 ± 0.00*

Values are means ± SE; the sample size n represents the number of rats per group. CON, control; M-CSF, macrophage colony-stimulating factor; MIP, macrophage inflammatory protein; PTH, parathyroid hormone; RANTES, regulated on activation normal T cell expressed and secreted.

^*Sample size was reduced to n = 1 because of undetectable limits for the respective cytokines in the physiological saline solution.