Fig. 7.

Structural components of the airway wall and the lung after 6 wk of treatment with either the shammed procedure or a 30-min constriction every other day. A: representative lung sections derived from mice subjected to either shammed procedures (left) or repeated constrictions (right) stained with trichrome. B: average area of airway smooth muscle per square length of basement membrane (BM) is displayed for mice subjected to shammed procedures (open bar) and repeated constrictions (closed bar). C: average of collagen content throughout the lung in fraction of the total tissue area is displayed for mice subjected to shammed procedures (open bar) and repeated constrictions (closed bar). D: representative lung sections derived from mice subjected to either shammed procedures (left) or repeated constriction (right) stained with periodic acid shift. Arrowheads point toward goblet cells. E: average number of goblet cell per millimeter of basement membrane is displayed for mice subjected to shammed procedures (open bar) and repeated constrictions (closed bar). F: average thickness of the airway epithelium is displayed for mice subjected to shammed procedures (open bar) and repeated constrictions (closed bar). *Statistically significant difference in mice subjected to repeated constrictions vs. mice subjected to shammed procedures. n = 10 mice per group.