Figure 7.
Effect of PL on synaptotoxicity in Aβ25–35 plaque-injected mice. After stereotaxic injection of Aβ25–35 plaque, mice were treated with vehicle, PL, or donepezil for 17 days. Synapses were stained with anti-SYN antibody or anti-PSD-95 antibody. The optical density of the SYN (A) and PSD-95 (B) were measured in the CA3; (C) Representative images of SYN (up) and PSD-95 (down) in the CA3 of mice brain. Scale bar = 30 μm. Values are mean ± standard error of the mean. ** p < 0.01 and *** p < 0.001 vs. sham group; # p < 0.05 vs. Aβ25–35 plaque group. Donepezil was used as a positive control.