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. 2018 Jun 12;19(6):1742. doi: 10.3390/ijms19061742

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effect of melatonin on EtOH-induced cellular senescence in PDLCs and cementoblasts. Cells are incubated with indicated concentration of melatonin (μM) and EtOH (25 mM) for 3 days (A–C). Senescence was examined by β-gal activity (A), ROS production (B,C) and expression of senescence-associated proteins (D) and mRNAs (E). These data are representative of three independent experiments. * statistically significant difference compared to the control groups (p < 0.05). ^# statistically significant difference in each group.