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Involvement of AMPK, mTOR and MAPK pathway on effects of melatonin in EtOH-induced senescence or differentiation in PDLCs and cementoblasts. Cells are pretreated with juglone (50 nM) or PIN1siRNA (30 nM) and then incubated with melatonin (100 μM) and EtOH (25 mM) for 60 min (A,B) and 45 min (C). Signal pathways was accessed by Western blot analysis. These data are representative of three independent experiments.
