PPAR |
Peroxisome Proliferator Activated Receptor |
NR |
Nuclear receptor |
TF |
Transcription factor |
AF-1 |
Activation-function 1 |
DBD |
DNA-binding domain |
LBD |
Ligand-binding domain |
RXRα |
Retinoic acid receptor α |
PPRE |
PPAR response element |
NCoR |
Nuclear receptor corepressor |
SMART |
Silencing mediator of retinoid and thyroid hormone receptor |
CBP |
CREB-binding protein |
SRC1 |
Steroid receptor coactivator 1 |
T2D |
Type 2 diabetes |
NAFLD |
Nonalcoholic fatty liver disease |
NASH |
Nonalcoholic steatosis |
TZD |
Thiazolidinedione |
BAT |
Brown adipose tissue |
FAO |
Fatty acid oxidation |
WAT |
White adipose tissue |
PTM |
Post-translational modification |
MAPK |
Mitogen-activated protein kinase |
CDK |
Cyclin-dependent kinase |
PGC1α |
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha |
XPD |
Xeroderma pigmentosum group D |
TFIIH |
Transcription factor II H |
GSKβ |
Glycogen synthase kinase β |
SUMO |
Small ubiquitin-like modifier |
GABP |
GA-binding protein |
MuRF1 |
Muscle-specific RING finger protein 1 |
EGF |
Epidermal growth factor |
PDGF |
Platelet-derived growth factor |
TGFβ |
Transforming growth factor β |
TPA |
12-O-tetradecanoyl-13-phorbol acetate |
PGF2α |
Prostaglandin F2α |
ERK |
Extracellular signal–regulated kinase |
MEK2 |
Dual specificity mitogen-activated protein kinase kinase 2 |
JNK |
c-Jun N-terminal kinase |
DOK1 |
Docking protein 1 |
HFD |
High fat diet |
PP5 |
Protein phosphatase 5 |
PPM1B |
Protein phosphatase Mg2+/Mn2+ dependent 1B |
WIP1 |
Wild-type p53-induced phosphatase 1 |
PER2 |
Period circadian regulator 2 |
GWAS |
Genome-wide association study |
THRAP3 |
Thyroid hormone receptor associated protein 3 |
LC-MS/MS |
Liquid chromatography-tandem mass spectrometry |
c-SRC |
SRC proto-oncogene, non-receptor tyrosine kinase |
PTP-1B |
Protein-tyrosine phosphatase 1B |
UBC9 |
Ubiquitin conjugating enzyme 9 |
PIAS |
Protein inhibitor of activated STAT |
SENP2 |
SUMO-specific protease 2 |
FGF21 |
Fibroblast growth factor 21 |
GDF11 |
Growth differentiation factor 11 |
SIRT1 |
NAD-dependent deacetylase sirtuin-1 |
PRDM16 |
PR domain containing 16 |
SIAH2 |
Seven in absentia homolog 2 |
MKRN1 |
Makorin RING finger protein 1 |
TRIM23 |
Tripartite motif containing 23 |
NEDD4 |
Neural precursor cell expressed, developmentally down-regulated 4 |
O-GlcNAc |
β-O-linked N-acetylglucosamine |
ChIP-seq |
Chromatin immunoprecipitation-sequencing |
SNP |
Single-nucleotide polymorphism |