Table 3.

The cytotoxicity of plant-mediated syntheses of metallic nanoparticles on animals (in vivo).

Subject	IC50	Toxicity	Exposure Duration	Response Relationship	Metallic Nanoparticle	Plant	Plant Part	Ref.	Year
Adult Zebrafish (Danio rerio)	142.2 ng/mL	Aggressive behaviours and jerky movements after 6 h of treatment prior to mortality; 100% mortality at 331.8 ng/mL (48 h); 100% mortality at 284.4 ng/mL (96 h)	96 h (Single dose)	Dose-dependent	Ag	Malva crispa	Leaf	[77]	2016
	Dose used = 71.1 ng/mL	Gill tissue cell membrane damage; irregular cell outlines and complete disruption of gill cells; evidence of genotoxicity in peripheral blood erythrocytes for AgNP exposed zebrafish	14 days (given once daily)	NA