Table 2.
Downregulated genes of selected enriched gene ontology categories following irradiation are shown on the basis of sets of statistically significant changes (p < 0.05) [108].
| GO:0006915: Apoptotic Process | GO:0008152: Metabolic Process |
| BCL2 binding component 3 (BBC3) | 1-acylglycerol-3-phosphate O-acyltransferase 2 (AGPAT2) |
| DCC netrin 1 receptor (DCC) | UDP glucuronosyltransferase family 1 member A1 (UGT1A1) |
| PYD and CARD domain-containing (PYCARD) | UDP glucuronosyltransferase family 1 member A10 (UGT1A10) |
| TNF receptor-associated factor 5 (TRAF5) | UDP glucuronosyltransferase family 1 member A3 (UGT1A3) |
| XIAP-associated factor 1 (XAF1) | UDP glucuronosyltransferase family 1 member A4 (UGT1A4) |
| Brain-expressed X-linked 2 (BEX2) | UDP glucuronosyltransferase family 1 member A5 (UGT1A5) |
| caspase 1 (CASP1) | UDP glucuronosyltransferase family 1 member A6 (UGT1A6) |
| cathepsin H (CTSH) | UDP glucuronosyltransferase family 1 member A7 (UGT1A7) |
| complement C5a receptor 1 (C5AR1) | UDP glucuronosyltransferase family 1 member A8 (UGT1A8) |
| engulfment and cell motility 1 (ELMO1) | UDP glucuronosyltransferase family 1 member A9 (UGT1A9) |
| interleukin 1 beta (IL1B) | acyl-CoA synthetase medium-chain family member 5 (ACSM5) |
| mitogen-activated protein kinase kinase 6 (MAP2K6) | acyl-CoA synthetase short-chain family member 1 (ACSS1) |
| nuclear receptor subfamily 4 group A member 1 (NR4A1) | acyl-CoA synthetase short-chain family member 3 (ACSS3) |
| phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1) | glutathione S-transferase mu 5 (GSTM5) |
| secreted frizzled related protein 2 (SFRP2) | haloacid dehalogenase-like hydrolase domain-containing 3 (HDHD3) |
| tyrosyl-tRNA synthetase (YARS) | lipase E, hormone sensitive type (LIPE) |
| mannosidase alpha class 1C member 1 (MAN1C1) | |
| GO:0072332: Intrinsic Apoptotic Signaling Pathway by p53 Class Mediator | |
| PERP, TP53 apoptosis effector (PERP) | GO:0007155: Cell Adhesion |
| PYD and CARD domain-containing (PYCARD) | CD22 molecule (CD22) |
| phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1) | CD9 molecule (CD9) |
| zinc finger matrin-type 1 (ZMAT1) | EPH receptor A4 (EPHA4) |
| zinc finger protein 385D (ZNF385D) | adhesion G protein-coupled receptor G1 (ADGRG1) |
| amelotin (AMTN) | |
| GO:2000406: Positive Regulation of T Cell Migration | basal cell adhesion molecule (Lutheran blood group) (BCAM) |
| PYD and CARD domain-containing (PYCARD) | brevican (BCAN) |
| TNF receptor superfamily member 14 (TNFRSF14) | cadherin 11 (CDH11) |
| integrin subunit alpha 4 (ITGA4) | collagen type IV alpha 6 chain (COL4A6) |
| fasciculation and elongation protein zeta 1 (FEZ1) | |
| GO:0002457: T Cell Antigen Processing and Presentation | fibulin 7 (FBLN7) |
| intercellular adhesion molecule 1 (ICAM1) | hemicentin 2 (HMCN2) |
| raftlin, lipid raft linker 1 (RFTN1) | hyaluronan synthase 1 (HAS1) |
| integrin subunit alpha 11 (ITGA11) | |
| GO:0002282: Microglial Cell Activation Involved in Immune Response | integrin subunit alpha 2 (ITGA2) |
| interleukin 33 (IL33) | integrin subunit alpha 4 (ITGA4) |
| toll like receptor 3 (TLR3) | integrin subunit alpha L (ITGAL) |
| integrin subunit beta 8 (ITGB8) | |
| GO:0007165: Signal Transduction | intercellular adhesion molecule 1 (ICAM1) |
| ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 (ARAP2) | junction plakoglobin (JUP) |
| G kinase anchoring protein 1 (GKAP1) | laminin subunit alpha 2 (LAMA2) |
| G protein subunit gamma 11 (GNG11) | laminin subunit alpha 3 (LAMA3) |
| GULP, engulfment adaptor PTB domain-containing 1 (GULP1) | ninjurin 1 (NINJ1) |
| KIT proto-oncogene receptor tyrosine kinase (KIT) | protein kinase C epsilon (PRKCE) |
| MX dynamin like GTPase 1 (MX1) | protein kinase, X-linked (PRKX) |
| NDP, norrin cystine knot growth factor (NDP) | protocadherin 17 (PCDH17) |
| NLR family pyrin domain-containing 12 (NLRP12) | sphingosine-1-phosphate receptor 1 (S1PR1) |
| NLR family pyrin domain-containing 3 (NLRP3) | trophoblast glycoprotein (TPBG) |
| PYD and CARD domain-containing (PYCARD) | versican (VCAN) |
| Ras association domain family member 9 (RASSF9) | |
| Rho family GTPase 2 (RND2) | GO:0045746: Negative Regulation Of Notch Signaling Pathway |
| SPARC-related modular calcium binding 1 (SMOC1) | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 (CHAC1) |
| TNF receptor-associated factor 5 (TRAF5) | MAGE family member A1 (MAGEA1) |
| TNF receptor superfamily member 11b (TNFRSF11B) | Hes-related family bHLH transcription factor with YRPW motif 1 (HEY1) |
| amyloid beta precursor protein binding family B member 1 interacting protein (APBB1IP) | maternally expressed 3 (non-protein coding) (MEG3) |
| androgen receptor (AR) | |
| basal cell adhesion molecule (Lutheran blood group) (BCAM) | GO:0010759: Positive Regulation of Macrophage Chemotaxis |
| calcitonin-related polypeptide beta (CALCB) | chemerin chemokine-like receptor 1 (CMKLR1) |
| caspase 1 (CASP1) | complement C5a receptor 1 (C5AR1) |
| chimerin 1 (CHN1) | tumor necrosis factor superfamily member 18 (TNFSF18) |
| complement C5a receptor 1 (C5AR1) | |
| fibroblast growth factor 18 (FGF18) | GO:0006351: Transcription, DNA-Templated |
| fibroblast growth factor 7 (FGF7) | CREB3 regulatory factor (CREBRF) |
| growth differentiation factor 15 (GDF15) | DNA damage inducible transcript 3 (DDIT3) |
| inositol-trisphosphate 3-kinase A (ITPKA) | E2F transcription factor 7 (E2F7) |
| insulin like growth factor binding protein 1 (IGFBP1) | HKR1, GLI-Kruppel zinc finger family member (HKR1) |
| insulin like growth factor binding protein 5 (IGFBP5) | Kruppel-like factor 2 (KLF2) |
| integrin subunit alpha L (ITGAL) | Kruppel-like factor 9 (KLF9) |
| interleukin 1 beta (IL1B) | MAGE family member A1 (MAGEA1) |
| interleukin 15 receptor subunit alpha (IL15RA) | MAX dimerization protein 1 (MXD1) |
| junction plakoglobin (JUP) | MLX interacting protein like (MLXIPL) |
| mitogen-activated protein kinase 10 (MAPK10) | NLR family pyrin domain-containing 3 (NLRP3) |
| mitogen-activated protein kinase kinase 6 (MAP2K6) | RAR related orphan receptor B (RORB) |
| nuclear receptor subfamily 2 group F member 1 (NR2F1) | SATB homeobox 1 (SATB1) |
| nuclear receptor subfamily 4 group A member 1 (NR4A1) | T-box 3 (TBX3) |
| nuclear receptor subfamily 4 group A member 2 (NR4A2) | TGFB-induced factor homeobox 2 like, X-linked (TGIF2LX) |
| phosphodiesterase 10A (PDE10A) | ZFP14 zinc finger protein (ZFP14) |
| phosphodiesterase 1A (PDE1A) | androgen receptor (AR) |
| phosphodiesterase 4D (PDE4D) | endoplasmic reticulum to nucleus signaling 1 (ERN1) |
| placental growth factor (PGF) | forkhead box P2 (FOXP2) |
| plasminogen activator, urokinase (PLAU) | hair growth associated (HR) |
| protein kinase AMP-activated catalytic subunit alpha 2 (PRKAA2) | hes-related family bHLH transcription factor with YRPW motif 1 (HEY1) |
| protein kinase C epsilon (PRKCE) | homeobox B7 (HOXB7) |
| protein kinase C zeta (PRKCZ) | homeobox B8 (HOXB8) |
| ras-related dexamethasone induced 1 (RASD1) | homeobox B9 (HOXB9) |
| ribosomal protein S6 kinase A2 (RPS6KA2) | interleukin 33 (IL33) |
| ribosomal protein S6 kinase A6 (RPS6KA6) | iroquois homeobox 5 (IRX5) |
| secreted and transmembrane 1 (SECTM1) | leucine zipper tumor suppressor 1 (LZTS1) |
| single Ig and TIR domain-containing (SIGIRR) | mitogen-activated protein kinase kinase 6 (MAP2K6) |
| thrombomodulin (THBD) | myelin expression factor 2 (MYEF2) |
| toll like receptor 3 (TLR3) | neuronal PAS domain protein 2 (NPAS2) |
| transducin-like enhancer of split 1 (TLE1) | nuclear factor I B (NFIB) |
| tumor necrosis factor superfamily member 10 (TNFSF10) | nuclear protein 1, transcriptional regulator (NUPR1) |
| tumor necrosis factor superfamily member 13b (TNFSF13B) | nuclear receptor coactivator 7 (NCOA7) |
| tumor necrosis factor superfamily member 18 (TNFSF18) | nuclear receptor subfamily 2 group F member 1 (NR2F1) |
| tyrosyl-tRNA synthetase (YARS) | nuclear receptor subfamily 4 group A member 1 (NR4A1) |
| unc-5 netrin receptor B (UNC5B) | nuclear receptor subfamily 4 group A member 2 (NR4A2) |
| unc-5 netrin receptor C (UNC5C) | protein kinase AMP-activated catalytic subunit alpha 2 (PRKAA2) |
| very low density lipoprotein receptor (VLDLR) | thyroid hormone receptor beta (THRB) |
| transducin-like enhancer of split 1 (TLE1) | |
| tribbles pseudokinase 3 (TRIB3) | |
| tumor protein p63 (TP63) | |
| twist family bHLH transcription factor 2 (TWIST2) | |
| vestigial-like family member 2 (VGLL2) | |
| visual system homeobox 1 (VSX1) | |
| zinc finger and SCAN domain containing 16 (ZSCAN16) | |
| zinc finger family member 788 (ZNF788) | |
| zinc finger protein 117 (ZNF117) | |
| zinc finger protein 138 (ZNF138) | |
| zinc finger protein 20 (ZNF20) | |
| zinc finger protein 273 (ZNF273) | |
| zinc finger protein 28 (ZNF28) | |
| zinc finger protein 30 (ZNF30) | |
| zinc finger protein 320 (ZNF320) | |
| zinc finger protein 354B (ZNF354B) | |
| zinc finger protein 396 (ZNF396) | |
| zinc finger protein 415 (ZNF415) | |
| zinc finger protein 419 (ZNF419) | |
| zinc finger protein 433 (ZNF433) | |
| zinc finger protein 44 (ZNF44) | |
| zinc finger protein 442 (ZNF442) | |
| zinc finger protein 443 (ZNF443) | |
| zinc finger protein 468 (ZNF468) | |
| zinc finger protein 521 (ZNF521) | |
| zinc finger protein 525 (ZNF525) | |
| zinc finger protein 528 (ZNF528) | |
| zinc finger protein 549 (ZNF549) | |
| zinc finger protein 563 (ZNF563) | |
| zinc finger protein 572 (ZNF572) | |
| zinc finger protein 577 (ZNF577) | |
| zinc finger protein 625 (ZNF625) | |
| zinc finger protein 649 (ZNF649) | |
| zinc finger protein 674 (ZNF674) | |
| zinc finger protein 680 (ZNF680) | |
| zinc finger protein 71 (ZNF71) | |
| zinc finger protein 761 (ZNF761) | |
| zinc finger protein 765 (ZNF765) | |
| zinc finger protein 792 (ZNF792) | |
| zinc finger protein 799 (ZNF799) | |
| zinc finger protein 806 (ZNF806) | |
| zinc finger protein 816 (ZNF816) | |
| zinc finger protein 83 (ZNF83) | |
| zinc finger protein 845 (ZNF845) | |
| zinc finger protein 85 (ZNF85) | |
| zinc finger protein 883 (ZNF883) | |
| zinc finger protein 888 (ZNF888) | |
| zinc finger with KRAB and SCAN domains 7 (ZKSCAN7) |