Table 1.

STAT3 activators.

Name	Mechanism	Cancer Type	Ref.
Hsp90	Chaperone activity via interaction with STAT3 N-terminal region	Hep3B cells	[37]
STIP1	Stabilization of JAK2 through its N-terminal domain, thereby promoting STAT3 phosphorylation, signal transduction and JAK2-HSP90-STAT3 complex assembly	MDAH2774, SKOV3 and ARK2 cells, primary ovarian tissues	[38]
STAP-2	Modulation of STAT3 activity upon phosphorylation by BRK	HeLa, MCF-7 and T47D cells	[39]
FGFR	Induction of STAT3 phosphorylation on tyrosine residues, nuclear translocation and activation of STAT3 target genes	HeLa and SUM-52PE cells	[40]
14-3-3ζ	Interacts with and prevents pSTAT3 Ser727 dephosphorylation by PP2A phosphatase	Multiple myeloma cells	[41]
MAGEC2	Interacts with and inhibits STAT3 polyubiquitination and proteasomal degradation	Human (A375) and mouse (B16) melanoma cell lines	[42]
Importin 3α	Binding to the nuclear localization sequence in the coiled-coil domain of unphosphorylated STAT3	HeLa and Hep3B cells	[43]
Importin 5α	Binding to tyrosine phosphorylated STAT3 at the N-terminal domain and maintenance of appropriate conformation	HepG2, MCF7 and HeLa cells	[44]
LANA	Interaction with STAT3 C-terminal domain and increased STAT3 transcriptional activity	KSHV-negative B lymphoma, DG75 and KSHV-positive BC3 cells	[45]
EBNA2	Increased STAT3 DNA-binding activity	HeLa cells	[46]
ARL2/BART	ARL2-GTP-BART complex is critical for STAT3 activation and nuclear translocation	Hep3B and HeLa cells	[47]
ARL3	Interaction with STAT3 DNA-binding domain and C-terminal domain, with consequent STAT3 phosphorylation	HeLa cells	[48]
Y14	Association with STAT3 C-terminal domain and positive regulation of STAT3 function	Hep3B cells	[49]
PASD1	Impairment of nuclear STAT3 dephosphorylation by TC45	HeLa cells, HeLa-derived xenografts in nude mice	[50]
PELP1	Increases STAT3 phosphorylation on Ser727 residue, facilitates STAT3 recruitment/retention in the target gene promoters	HeLa and MCF-7 cells	[51]
JAB1	Increases unphosphorylated STAT3 DNA-binding activity	Colo205 colon cancer cells	[52]
Progranulin	Regulation of STAT3 phosphorylation, nuclear translocation and transcriptional activity	TNBC cell lines. Primary breast cancer samples	[53]
CRIF1	Association with STAT3 C-terminal coiled-coil domain and positive regulation of STAT3 transcription activity	HeLa, HCT-116, SNU387 and MDA-MB 468 cells	[54]
	Binding and suppression of the androgen receptor transcription activity and coactivation of STAT3	CWR-R1 cells and surgical specimens of prostate	[55]
EGFR	Acts as a transcriptional co-activator of STAT3	Panc-1 and Colo-357 pancreatic cancer cell lines	[56]
p300/CREB	Regulation of Lys 685 acetylation, critical for STAT3 to form stable dimers and required for DNA binding	HeLa, MCF-7 and HepG2 cells	[21,57]
NcoA/SRC1a	Associates with p300/CBP and acts as a cofactor to potentiate STAT3 transcriptional activity	HepG2 cells	[58]
HDAC3	Modulation of STAT3 Lys685 acetylation and Tyr705 phosphorylation	Ly3 and DHL2 DLBCL cell lines	[59]
TOM20	Regulates STAT3 mitochondrial import and oncogenic functions	Human pancreatic cell lines. BxPC-3-and MIA PaCa-2-derived xenografts in nude mice	[60]

TNBC = Triple-Negative Breast Cancer; DLBCL = Diffuse Large B-Cell Lymphoma.