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. 2018 May 31;19(6):1626. doi: 10.3390/ijms19061626

Figure 6.

Figure 6

Effects of OA on mitogen-activated protein kinase (MAPK) pathway. (A) ELISA of IL-8 and IL-10 in the serum. Groups were as described in “Methods: animals”. The experiments were repeated at least three times. The results are presented as the mean ± SD. * p < 0.05, compared with the control. # p < 0.05, compared with the CLI group; (B) Western blot of interleukin-8 (IL-8) and IL-10 in the serum. Groups were as described in “Methods: animals”; (C) Western blot of tumor necrosis factor-α (TNF-α), p-JNK, N-terminal kinase (JNK), p-p38, and p38 mitogen-activated protein kinase (p-38) in the LO-2 cells. Groups were as described in “Methods: Cell line and Reagents”; (D) Western blot of Bcl-2, Bax, Caspase3, Cleaved-caspase3, β-actin in the LO-2 cells; (E) Immunohistochemistry of p-JNK, p-p38 in the tissues (400×). Groups were as described in “Methods: animals”; (F) Schematic presentation of hepatoprotective effect of OA in the liver.