Skip to main content
. 2018 Jun 15;19(6):1785. doi: 10.3390/ijms19061785

Figure 4.

Figure 4

Time profiles of cellular rifampicin concentration, PXR/RXRα heterodimer abundance, and CYP3A4 protein induction in primary human hepatocytes with different rates of CYP3A4-mediated metabolism employing the model by Luke et al., 2010. Rifampicin was applied at the concentration of 10 μM every 12 h. In the upper figures, the feedback metabolism constant kmet equals kmet = 2.47 × 10−4, in the middle figures it equals kmet = 2.47 × 10−5, and in the lower figures it equals kmet = 2.47 × 10−6.