Figure 3.
Aged animals have greater CCR2 ligand expression at 4 and 7 days post-injury (dpi). (A,B) Quantitative PCR data for CCL2 and CCL7 expression in the hippocampus ipsilateral to injury. At 4 and 7 dpi, there was no difference between aged and young animals in CCL2 and CCL7 expression at 4 dpi, but there was a trend for decreased expression in young animals by 7 dpi. (C,D) Quantitative PCR data for CCL8 and CCL12 expression in the hippocampus ipsilateral to injury. Aged animals have significantly higher CCL8 and CCL12 expression at both 4 and 7 dpi (n = 7–9; two-way ANOVA, significant main effect of age only, no significant interactions, ** p < 0.01, *** p < 0.001).