Table 1.
Long-term hypoxia and potency of bradykinin-induced relaxation
| Normoxic |
Hypoxic |
|||
|---|---|---|---|---|
| Condition | Mean ± SE | n | Mean ± SE | n |
| Control | −8.72 ± 0.11 | 11/40 | −7.34 ± 0.25b | 16/28 |
| l-NAME | −8.70 ± 0.37 | 4/9 | −7.40 ± 0.47 | 7/15 |
| Indo | −7.95 ± 0.13 | 3/11 | −7.21 ± 0.36 | 4/10 |
| TEA | −7.66 ± 0.39a | 3/6 | −7.47 ± 0.13 | 5/7 |
Values are log concentration for the IC50 for bradykinin-induced relaxation for data presented graphically in Figs. 1, 4, 6, and 7; n, no. of arteries studied for each condition in each group. l-NAME, NG-nitro-l-arginine methyl ester; Indo, indomethacin; TEA, tetraethylammonium. aSignificant leftward shift in the IC50 compared with control and bsignificant difference in IC50 compared with normoxic counterpart [with the use of a 95% confidence interval based on the log(inhibitor) vs. response curve fit to the data].