Table 2.
Long-term hypoxia and efficacy of bradykinin-induced relaxation
| Normoxic |
Hypoxic |
|||
|---|---|---|---|---|
| Condition | Mean ± SE | n | Mean ± SE | n |
| Control | 33 ± 2 | 11/40 | 40 ± 6 | 16/28 |
| l-NAME | 57 ± 4a | 4/9 | 56 ± 14 | 7/15 |
| Indo | 36 ± 3 | 3/11 | 47 ± 16 | 4/10 |
| TEA | 52 ± 6a | 3/6 | 24 ± 4 | 5/7 |
Values are percentage of TKmax for bradykinin induced relaxation for data presented graphically in Figs. 1, 4, 6, and 7; n, no. of arteries studied for each condition in each group. l-NAME, NG-nitro-l-arginine methyl ester; Indo, indomethacin; TEA, tetraethylammonium. aSignificant depression in efficacy compared with control [using a 95% confidence interval based on the log(inhibitor) vs. response curve fit to the data].