Fig. 4.

Anti-dopamine-β-hydroxylase-conjugated saporin (DSAP) alters distribution of carbohydrate, but not fat, calories. A: average daily calorie intake and terminal body weight were significantly correlated in mouse IgG-saporin conjugate (MSAP; dashed line; y = 1.698x + 321.84, R² = 0.741, F = 31.43, df 1,11, P < 0.0002, n = 12) and DSAP (solid line; y = 2.352x + 290.37, R² = 0.790, F = 49.02, df 1,11, P < 0.0001, n = 12) animals. Slopes of the two regression lines were not significantly different. B: average daily calorie intake and visceral fat mass were significantly correlated in MSAP (dashed line; y = 1.70x + 321.84, R² = 0.741, F = 31.43, df 1,11, P < 0.0002, n = 12) and DSAP (solid line; y = 2.352x + 290.37, R² = 790, F = 49.02, df 1,11, P < 0.0001, n = 12) animals. Slopes of the two regression lines were significantly different (P < 0.05). C: average daily intake of total carbohydrate (CHO) and visceral fat mass were tightly correlated in MSAP (dashed line; y = 0.03x + 2.18, R² = 0.852, F = 63.34, df 1,11, P < 0.0001, n = 12) and DSAP (solid line; y = 0.056x − 1.24, R² = 0.861, F = 67.98, df 1,11, P < 0.0001, n = 12) animals. Slopes of the two regression lines were significantly different (P < 0.002). D: average daily fat intake and terminal weight of visceral fat were significantly correlated in MSAP (dashed line; y = 1.018x + 1.199, R² = 0.456, F = 8.41, df 1,10, P < 0.02, n = 11) and DSAP (solid line; y = 0.153x + 3.197, R² = 0.688; F = 24.28, df 1,11, P < 0.0005. n = 12) animals. Slopes of the two regression lines were not significantly different. ns, Not significant.