Table 3.
Plasma and blood glucose concentrations, and uterine and umbilical glucose uptakes on the final day of saline or cortisol infusion or 5 days thereafter
| During Infusion |
+5 Days Postinfusion |
P Value (Two-Way ANOVA) |
|||||
|---|---|---|---|---|---|---|---|
| Saline (n = 15) | Cortisol (n = 9) | Saline (n = 10) | Cortisol (n = 9) | Cortisol | Study day | Interaction | |
| Arterial plasma glucose, mM | |||||||
| Maternal | 3.23 ± 0.13 | 3.59 ± 0.18 | 3.20 ± 0.10 | 2.93 ± 0.16 | 0.76 | 0.03 | 0.04 |
| Fetal | 0.90 ± 0.05 | 1.20 ± 0.09* | 0.96 ± 0.05 | 0.77 ± 0.05* | 0.38 | <0.01 | <0.01 |
| Gradient | 2.33 ± 0.11 | 2.39 ± 0.15 | 2.24 ± 0.11 | 2.16 ± 0.14 | 0.95 | 0.21 | 0.57 |
| Arterial blood glucose, mM | |||||||
| Maternal | 2.42 + 0.13 | 2.71 + 0.17 | 2.28 + 0.08 | 2.05 + 0.09 | 0.82 | <0.01 | 0.05 |
| Fetal | 0.80 + 0.04 | 1.16 + 0.08* | 0.79 + 0.06 | 0.73 + 0.05 | 0.02 | <0.01 | <0.01 |
| Uterine glucose uptake, µmol/min | 197 + 14 | 242 + 36 | 255 + 19 | 238 + 24 | 0.54 | 0.24 | 0.17 |
| Glucose consumption | |||||||
| Umbilical, µmol/min | 91 + 6 | 67 + 4* | 88 + 8 | 54 + 9* | <0.01 | 0.27 | 0.48 |
| Umbilical, µmol·min−1·kg fetus−1 | 31 + 2 | 22 + 1* | 25 + 2 | 16 + 3* | <0.01 | 0.01 | 0.98 |
| Uteroplacental, µmol/min | 106 + 14 | 176 + 35 | 168 + 21 | 184 + 31 | 0.08 | 0.16 | 0.28 |
Values are means ± SE.
*
P < 0.05 vs. saline, least significant difference post hoc test. Boldface values indicate significant effect by two-way ANOVA.