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. 2018 May 24;19(6):1567. doi: 10.3390/ijms19061567

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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STAT3 specific inhibitors suppress HSC activation. (a) LX-2 and HSC-T6 cell viability after treatment with varying concentrations of STAT3 specific inhibitor stattic for 48 h; (b) LX-2 and HSC-T6 cell viability after treatment with varying concentrations of STAT3 specific inhibitor SH-4-54 for 48 h; (c) Western blot with LX-2 whole cell lysate after incubation with vehicle, 1.5 µM of stattic, or 0.5 µM of SH-4-54 for 72 h for α-SMA. Densitometric analyses of bands were quantified and data expressed as fold of control normalized to Glyceraldehyde 3-phosphate dehydrogenase (GAPDH). P-values shown compared to vehicle. The results are representative of at least 3 independent experiments. All summary bar and line graphs are presented as mean ± SEM, with significance denoted as follows **: p < 0.01, ***: p < 0.001.

STAT3 specific inhibitors suppress HSC activation. (a) LX-2 and HSC-T6 cell viability after treatment with varying concentrations of STAT3 specific inhibitor stattic for 48 h; (b) LX-2 and HSC-T6 cell viability after treatment with varying concentrations of STAT3 specific inhibitor SH-4-54 for 48 h; (c) Western blot with LX-2 whole cell lysate after incubation with vehicle, 1.5 µM of stattic, or 0.5 µM of SH-4-54 for 72 h for α-SMA. Densitometric analyses of bands were quantified and data expressed as fold of control normalized to Glyceraldehyde 3-phosphate dehydrogenase (GAPDH). P-values shown compared to vehicle. The results are representative of at least 3 independent experiments. All summary bar and line graphs are presented as mean ± SEM, with significance denoted as follows **: p < 0.01, ***: p < 0.001.