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Cur binds to Aβ-plaques greater than classical amyloid binding dyes. (A) Curcumin has structural similarities with classical amyloid binding dyes. (B) Upper panel: Cryostat sections from 5XFAD mouse hippocampus were stained with Thio-S, Congo-red, Cur and Aβ-specific antibody (6E10). Please note that Cur stained Aβ plaques are more visible than other dyes. Lower panel: Cur is co-localized with Aβ-specific antibody (6E10) in Aβ-plaques in mouse cortical tissue from 5xFAD.
