Table 9.
List of a few clinical trials with Cur in Alzheimer’s disease.
| Study ID | Curcumin Molecule | Cohort | Dose | Duration | Outcomes | Ref. |
|---|---|---|---|---|---|---|
| Baum et al. NCT00164749 | Cur + gingko | AD:50+ year, n= 30 | 1, 4 g/day | 6 months | No differences in Aβ levels between treatments or MMSE scores | [71] |
| Ringman et al. (ACT00099710) | Cur C3 complex | Mid/Moderate AD, 49 y+, n = 30 | 2, 4 g/day | 24 weeks | No differences detected between treatment groups in biomarkers measured, low bioavailability | [197] |
| Hishikawa et al. | Tumeric capsule | Severe AD, n = 3 | 100 mg/day | 12 months tested after 12 weeks | MMSE and NPIQ; score on NPIQ decreased significantly, MMSE increased in 1/3 | [198] |
| Poncha (NCT01001637) | Longvida | Moderate-severe AD, 50–80 y, n = 160 | 2, 3 g/twice daily | 2 months | Efficacy and safety: blood and cognition | [199] |
| Martin and Goozee (ACTRN12613000681752) | Biocurucmax (BCM-95) | Retirement, healthy, 65–95, n = 100 | 500 mg/thrice/day | 12 months | Cognition, blood biomarkers, brain imaging, retinal imaging | [199] |
| Martin (ACTRN12611000437965) | Biocurucmax (BCM-95) | Community living, healthy, 55–75, n = 100 | 500 mg/thrice/day | 12 months | Cognition, blood biomarkers, life style, brain imaging | [199] |
| Small et al. (NCT01383161) | Tetracurcumin CR-031PTM | MCI, normal aging, n = 132 | 90 mg/twice/day | 18 months | Cognition, blood genetic profile | [200] |
| Frautschy (NCT018811381) | Longvida and Yoga | Subjective cognitive complainers, 55–90, n = 80 | 400 mg/twice/daily | 6 months | Biochemistry, cognition, brain imaging | [199] |
| Cox et al. (ACTRN12612001027808) | LongvidaTM | Healthy and cognitive decline, 65–80, n= 60 | 400, 800 mg/daily | 4weeks 8 weeks | Cognition, mood and anxiety, blood biomarkers, MRI | [201] |
| NCT00595582 | Curcumin bioperine | MCI, 55–85, n = 10 | 900 mg/twice/daily | 24 months | Cognition and size of metabolic lesion by PET | [199] |
| ACTRN12614001024639 | BCM-95 | Healthy and MCI, 65–90 years, n = 48 | 500 mg/twice/daily | 3 months | Gene regulation and expression, and cognition | [199] |
| ACTRN12613000367741 | LongvidaTM | Healthy, MCI, mild/moderate AD, 50 years, n = 200 | 20 g/daily | 7 days | Diagnostics, Curcumin fluorescent retinal imaging of Aβ plaques | [199] |