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(A) Potential energy versus time of HuPrP(120–144) peptides aggregating in the presence of U‐, S‐, Ω‐shaped Hu seeds. (B) Average sidechain interaction energy per peptide of U‐, S‐, Ω‐shaped HuPrP(120–144) protofilaments (seeds). (C) Potential energy versus time of Hu, BV, and ShaPrP(120–144) peptides aggregating in the presence of S‐shaped Hu, Ω‐shaped BV, and Ω‐shaped Sha seeds. (D) Average sidechain interaction energy per peptide of S‐shaped Hu, Ω‐shaped BV, and Ω‐shaped Sha seeds.
