Five types of structural mismatches found in homogeneous and heterogeneous protofilaments formed by Hu, BV, and SHaPrP(120–144) peptides. Simulation snapshot of (A) Hu with the Ω‐shaped SHa protofilament from the 2nd run; (B) BV with the Ω‐shaped SHa protofilament from the 3rd run; (C) BV with the Ω‐shaped SHa protofilament from the 4th run; (D) SHa with the Ω‐shaped BV protofilament from the 2nd run; (E) SHa with the Ω‐shaped SHa protofilament from the 1st run. Hu, BV, and SHaPrP(120–144) peptides in A–E are colored in red, blue and green, respectively, except that the SHa(120–144) monomer peptides in E are colored in purple.