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. 2018 May 31;19(6):1631. doi: 10.3390/ijms19061631

Figure 8.

Figure 8

Schematic representation of the Notch-1/EGFR axis in U87 cells. (A) In U87 cells, the downregulated expression of mir-34a-5p caused the up-regulation of Notch-1 expression with consequent increased expression of EGFR. The up-regulation of these two receptors causes increased cell proliferation. (B) M2 muscarinic receptors up-regulate the expression of mir-34a-5p, which prevents the increased levels of Notch-1. The down-regulation of Notch-1 negatively affects cell proliferation by the down-regulated expression of EGFR.