Table 1.

Negative effects of MgD on the body and organs.

General: anxiety, agitation, irritability, headache, loss of appetite, nausea.

Musculature: muscle spasm and tetany.

CNS/Nerves: nervousness, migraine, depression, poor memory, low stress tolerance, paraesthesia, tremor, and seizures.

Cardiovascular system: HTN, risk of arrhythmias, coronary spasm, atherosclerosis, endothelial dysfunction, low-grade vascular inflammation, arterial stiffness, vascular ECM remodeling, arterial calcification, vascular aging, increased platelet aggregation, potentiates Ca2+-mediated vasoconstriction, potentiates the vasoconstrictor effects of ATII, ET-1, NA, Adr, and TxA2.

Electrolytes: sodium retention, hypokalemia, and hypocalcemia.

Metabolism: dyslipoproteinemia, insulin resistance, pancreatic β-cell dysfunction, decreased glucose tolerance, increased risk of MetS and T2D, disorders of vitamin D metabolism, resistance to PTH, and osteoporosis.

Pregnancy: pregnancy complications (e.g., eclampsia).

Gastrointestinal tract: constipation.