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. 2018 May 31;19(6):1628. doi: 10.3390/ijms19061628

Figure 1.

Figure 1

The FAS1 domain across kingdoms of life. (A) Delta-BLAST alignment of some FAS1 domains mentioned in this article. Note the conservation of the N and C-proximal H1 and the H2 region as well as the central YH motif. The sequences used by Delta-BLAST were HsTgfbi (NP_000349.1), HsPn (gi 93138709), DsFas1 FAS1-3 (1O70_A), Algal-CAM (gi 75282282), AtFLA11 (gi 116247778), AtFLA4 (gi 75206907), MbMpb83 (gi 614094354), and SmNex18 (gi 81635876). Red/blue indicates highly/not conserved residues; color bits threshold set to 2.5; (B) The general topology of the FAS1 domain features is reminiscent of the “thumbs-up” gesture. The secondary structure of HsTgfbi FAS1-1 is annotated omitting the three N-terminal helices for clarity; (C) The crystal structure of HsTgfbi FAS1-1 [33] in ribbon display.