Figure 2.

Cell adhesion assay. (A) On an uncoated or control-coated (red) plastic substrate, cell adhesion is inefficient; (B) cells adhere rapidly when plastic is coated with an adhesion protein such as Tgfbi or Pn (green); (C) to identify the receptor for the adhesion protein, integrin isotype specific antibodies (red) are co-incubated; (D) mammalian FAS1 proteins are thought to bind to different types of dimeric integrins (blue and yellow) that mediate mechanical contact between the cytoskeleton (grey) and the ECM as well as transduce intracellular signals using numerous associated proteins (pink and nude).