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. 2018 Jun 9;19(6):1715. doi: 10.3390/ijms19061715

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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iPSC-Exo restored the altered expression of specific dermal markers in senescent HDFs. After treatment with 20 × 10⁸ particles/mL iPSC-Exo for 24 h in serum-free DMEM/F12, HDFs were harvested after 48 h. The mRNA expression levels of collagen type I (A); MMP-1 (B); and MMP-3 (C) were quantified by quantitative real-time RT-PCR. ** p < 0.01, *** p < 0.001. Error bars indicate standard deviations of triplicate samples in a single representative experiment.

iPSC-Exo restored the altered expression of specific dermal markers in senescent HDFs. After treatment with 20 × 10⁸ particles/mL iPSC-Exo for 24 h in serum-free DMEM/F12, HDFs were harvested after 48 h. The mRNA expression levels of collagen type I (A); MMP-1 (B); and MMP-3 (C) were quantified by quantitative real-time RT-PCR. ** p < 0.01, *** p < 0.001. Error bars indicate standard deviations of triplicate samples in a single representative experiment.