TABLE 5.
TOP GENES, BIOLOGICAL FUNCTION, GENE ONTOLOGY, AND CHROMOSOMAL LOCATION
| Gene Symbol | Biological Function | Gene Ontology* | Location | |
|---|---|---|---|---|
| Process | Component | |||
| MRPS6 | Structural constituent of ribosome | Protein biosynthesis | Mitochondrial small ribosomal subunit | 21q21.3-q22.1 |
| HIST1H2BD | DNA binding | Chromosome organization and biogenesis, nucleosome assembly | Nucleus, chromosome, nucleosome | 6p21.3 |
| RBM3 | RNA processing | RNA, nucleotide, nucleic acid binding | N/A | Xp11.2 |
| SLC38A2 | A sodium-coupled neutral amino acid transporter (16)† | Glutamate–glutamine cycle/gultamine transporter (16)† | N/A | 12q |
| CHORDC1 | Heat shock protein 90-interacting protein (17)† | N/A | N/a | 11q14.3 |
| CIRBP | RNA, nucleotide and nucleic acid binding | Response to cold | Nucleus | 19p13.3 |
| FLJ33814 | N/A | N/A | N/A | 22q12.1 |
| FUSIP1 | RNA splicing factor activity, transesterification mechanism, RS domain binding, unfolded protein binding | Assembly of spliceosomal tri-snRNP, cytoplasmic transport,mRNA export from nucleus, mRNA splice site selection, nuclear mRNA splicing, via spliceosome, regulation of transcription | Cytoplasm, nucleoplasm, nucleus | 1p36.11 |
| PRKACB | ATP binding, cAMP-dependent protein kinase activity, magnesium ion binding, nucleotide binding, protein serine/threonine kinase activity, transferase activity | G-protein signaling, coupled to cAMP nucleotide second messenger, protein amino acid phosphorylation, signal transduction | cAMP-dependent protein kinase complex, nucleus | 1p36.1 |
| STIP1 | Binding | Response to stress | Golgi apparatus, nucleus | 11q13 |
| SUV420H1 | Histone lysine N-methyltransfease | Histone methylation | Condensed nuclear chromosome, pericentric region | 11q13.2 |
N/A, not assigned.
*
Annotated from Entrez Gene (http://www.ncbi.nlm.nih.gov).
†
Proposed biological function (see reference).
‡
Drosophila analogue.