TABLE 1.
ZOXAZOLAMINE PARALYSIS TEST
PRIP+/+ | PRIPLiv−/− | |
---|---|---|
Control | 4/13: 2-h paralysis; recovered | 1/11: 2-h paralysis; recovered |
5/13: 3-h paralysis; recovered | 6/11: 3-h paralysis; recovered | |
1/13: 4-h paralysis; recovered | 1/11: 4-h paralysis; dead | |
1/13: 6-h paralysis; recovered | 1/11: 8-h paralysis; dead | |
1/13: 6-h paralysis; dead | 2/11: 12-h paralysis; recovered | |
1/13: 9-h paralysis; dead | ||
PB (3 days) | 8/8: not paralyzed | 8/8: not paralyzed |
Control and 3-day PB-treated male mice (5–6 weeks old) were given a single IP injection of zoxazolamine (300 mg/kg of body weight), and paralysis duration was recorded as the time when the mice were able to right themselves repeatedly. Very similar results were observed in both wild-type (PRIP+/+) and knockout (PRIP−/−) mouse groups.