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. 2018 Jul 5;13(4-5):217–226. doi: 10.3727/000000006780666957

Figure 2.

Figure 2

MSC elicit more significant suppression of T-cell proliferation in MLCs with, compared to MSC without, cell contact. Proliferation of responder CD2+ cells with allogeneic PBMCs (gray column) or cocultured with MSC in increasing MSC/T cell ratios with (white column) and without (black column) cell contact. The mean CPM of CD2 + PBMC pairs in the absence of MSC is assigned a 100% value ± SEM (gray columns). The percentage of proliferative response was the mean of a given MSC/TL ratio divided by the mean of CD2 + PBMC proliferation. *A statistically significant inhibition of the proliferation of CD2+ cells was observed, compared with the control (CD2 + PBMC) (p = 0.001). **A statistically significant value was observed when comparing the inhibitory effect between cultures with and without cell contact (p = 0.003 for the MSC/TL ratio 0.3 and p = 0.05 for the MSC/T cell ratio 0.1).