TABLE 3.
GENES WITH MOST SIGNIFICANT CHANGES IN EXPRESSION BETWEEN TREATED AND UNTREATED GROUPS
| GenBank Accession No. | Description | Mean ± SD of Control | Mean ± SD of DMN Treatment | Fold Change | p-Value |
|---|---|---|---|---|---|
| Downregulated genes | |||||
| X14552 | Protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), alpha isoform | 10.58 ± 4.22 | 0.70 ± 0.29 | ↓ 15.2 | <0.0001 |
| D14564 | Rattus norvegicus gene for l-gulono-gamma-lactone oxidase, exon 7 | 3.07 ± 0.69 | 0.49 ± 0.28 | ↓ 6.2 | <0.0001 |
| M64755 | Cysteine-sulfinate decarboxylase | 3.26 ± 1.28 | 0.53 ± 0.29 | ↓ 6.2 | <0.0001 |
| AA893325 | Ornithine aminotransferase | 4.41 ± 1.12 | 0.83 ± 0.29 | ↓ 5.3 | <0.0001 |
| M93297 | Rattus norvegicus ornithine aminotransferase (rOAT) gene, exon 7 | 4.10 ± 1.51 | 0.78 ± 0.19 | ↓5.3 | <0.0001 |
| AA892345 | Rat mRNA for dimethylglycine dehydrogenase (EC number 1.5.99.2) | 2.72 ± 0.71 | 0.53 ± 0.29 | ↓ 5.1 | <0.0001 |
| J05210 | ATP citrate lyase | 2.93 ± 1.58 | 0.60 ± 0.33 | ↓ 4.9 | 0.00031 |
| AA893552 | Rattus norvegicus kallistatin mRNA, complete cds | 2.70 ± 0.52 | 0.65 ± 0.27 | ↓ 4.1 | <0.0001 |
| M00002 | Apolipoprotein A-IV | 2.99 ± 1.34 | 0.75 ± 0.31 | ↓ 4.0 | <0.0001 |
| D00362 | Rattus norvegicus mRNA for carboxyesterase E1, partial cds | 1.33 ± 0.24 | 0.33 ± 0.24 | ↓ 4.0 | <0.0001 |
| AI232087 | Hydroxyacid oxidase 3 (medium-chain) | 2.43 ± 0.52 | 0.62 ± 0.34 | ↓ 3.9 | <0.0001 |
| X52625 | 3-Hydroxy-3-methylglutaryl-Coenzyme A synthase 1 | 2.65 ± 0.77 | 0.69 ± 0.27 | ↓ 3.8 | <0.0001 |
| S49003 | Short isoform growth hormone receptor (rats, mRNA, 1136 nt) | 1.93 ± 0.42 | 0.52 ± 0.23 | ↓ 3.7 | <0.0001 |
| M22359 | Alpha(1)-inhibitor 3, variant I | 2.12 ± 1.03 | 0.57 ± 0.43 | ↓ 3.7 | 0.00024 |
| AF038870 | Betaine-homocysteine methyltransferase | 2.04 ± 0.30 | 0.55 ± 0.24 | ↓ 3.7 | <0.0001 |
| H31813 | ESTs, moderately similar to T14781 hypothetical protein DKF-Zp586B1621.1 (H. sapiens) | 1.92 ± 0.59 | 0.55 ± 0.29 | ↓ 3.5 | <0.0001 |
| M59861 | 10-Formyltetrahydrofolate dehydrogenase | 1.86 ± 0.37 | 0.54 ± 0.28 | ↓ 3.5 | <0.0001 |
| M77479 | Solute carrier family 10 (sodium/bile acid cotransporter family), member 1 | 1.66 ± 0.45 | 0.48 ± 0.36 | ↓ 3.4 | <0.0001 |
| M22993 | Alpha(1)-inhibitor 3, variant I | 2.32 ± 1.84 | 0.69 ± 0.45 | ↓ 3.3 | 0.01129 |
| U32314 | Pyruvate carboxylase | 1.88 ± 0.40 | 0.57 ± 0.31 | ↓ 3.3 | <0.0001 |
| AA891774 | ESTs, similar to RIKEN cDNA 1810013B01 | 1.76 ± 0.28 | 0.54 ± 0.24 | ↓ 3.3 | <0.0001 |
| U39206 | Rattus norvegicus cytochrome P450 4F4 (CYP4F4) mRNA, complete cds | 1.87 ± 0.44 | 0.58 ± 0.40 | ↓ 3.2 | <0.0001 |
| M16235 | Lipase, hepatic | 1.74 ± 0.40 | 0.55 ± 0.28 | ↓ 3.2 | <0.0001 |
| AF097723 | Plasma glutamate carboxypeptidase | 1.86 ± 0.30 | 0.60 ± 0.24 | ↓ 3.1 | <0.0001 |
| M26127 | Rat cytochrome P-450 ISF/BNF-G mRNA | 1.76 ± 0.46 | 0.57 ± 0.38 | ↓ 3.1 | <0.0001 |
| AA893032 | ESTs, NAD(P) dependent steroid dehydrogenase-like | 1.70 ± 0.46 | 0.55 ± 0.28 | ↓ 3.1 | <0.0001 |
| D90109 | Fatty acid Coenzyme A ligase, long chain 2 | 1.65 ± 0.37 | 0.54 ± 0.28 | ↓ 3.1 | <0.0001 |
| AA926193 | Sulfotransferase family, cytosolic, 1C, member 2 | 1.81 ± 0.35 | 0.60 ± 0.31 | ↓ 3.0 | <0.0001 |
| U10697 | Carboxylesterase 1 | 1.70 ± 0.37 | 0.57 ± 0.32 | ↓ 3.0 | <0.0001 |
| X76456 | Unnamed protein product; R. norvegicus (Sprague Dawley) alpha albumin gene | 1.72 ± 0.52 | 0.58 ± 0.26 | ↓ 2.9 | <0.0001 |
| AA893244 | ESTs, 3′-phosphoadenosine 5′-phosphosulfate synthase 2 (pre-dieted) | 2.20 ± 0.54 | 0.75 ± 0.24 | ↓ 2.9 | <0.0001 |
| AA893495 | ESTs, highly similar to CORTICOSTEROID-BINDING GLOBULIN PRECURSOR (R. norvegicus) | 1.52 ± 0.32 | 0.52 ± 0.33 | ↓ 2.9 | <0.0001 |
| U72497 | Fatty acid amide hydrolase | 1.84 ± 0.32 | 0.63 ± 0.21 | ↓ 2.9 | <0.0001 |
| S46785 | Insulin-like growth factor binding protein complex acid-labile subunit (rats, liver, mRNA, 2190 nt) | 1.91 ± 0.50 | 0.66 ± 0.38 | ↓ 2.9 | <0.0001 |
| D00752 | Serine protease inhibitor | 1.60 ± 0.34 | 0.55 ± 0.31 | ↓ 2.9 | <0.0001 |
| AA859994 | ESTs, cDNA clone IMAGE:7308494 | 1.85 ± 0.51 | 0.64 ± 0.16 | ↓ 2.9 | <0.0001 |
| U68168 | Kynureninase (l-kynurenine hydrolase) | 1.81 ± 0.48 | 0.64 ± 0.41 | ↓ 2.8 | <0.0001 |
| AA817846 | 3-Hydroxybutyrate dehydrogenase (heart, mitochondrial) | 1.63 ± 0.43 | 0.57 ± 0.38 | ↓ 2.8 | <0.0001 |
| AF080468 | Glucose-6-phosphatase, transport protein 1 | 1.62 ± 0.45 | 0.58 ± 0.26 | ↓ 2.8 | <0.0001 |
| U39943 | Rattus norvegicus cytochrome P450 pseudogene (CYP2J3P1) mRNA | 1.49 ± 0.20 | 0.53 ± 0.30 | ↓ 2.8 | <0.0001 |
| AA892916 | ESTs, similar to RIKEN cDNA 2310001A20 (predicted) | 1.98 ± 0.68 | 0.71 ± 0.20 | ↓ 2.8 | <0.0001 |
| U04733 | Arachidonic acid epoxygenase | 1.44 ± 0.26 | 0.51 ± 0.43 | ↓ 2.8 | <0.0001 |
| AA859645 | Attractin | 2.11 ± 0.53 | 0.76 ± 0.20 | ↓ 2.8 | <0.0001 |
| AA859899 | ESTs, hypothetical protein XP_379516 (Homo sapiens) | 1.67 ± 0.48 | 0.60 ± 0.23 | ↓ 2.8 | <0.0001 |
| AA799560 | N-myc downstream-regulated gene 2 | 1.55 ± 0.22 | 0.56 ± 0.30 | ↓ 2.8 | <0.0001 |
| S76489 | This sequence comes from Figure 1; estrogen sulfotransferase isoform 3 (rats, male, liver, mRNA, 1000 nt) | 1.46 ± 0.21 | 0.53 ± 0.33 | ↓ 2.7 | <0.0001 |
| Ml1266 | Ornithine carbamoyltransferase | 1.55 ± 0.27 | 0.56 ± 0.28 | ↓ 2.7 | <0.0001 |
| M67465 | Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase | 1.80 ± 0.53 | 0.66 ± 0.36 | ↓ 2.7 | <0.0001 |
| M13646 | Rattus norvegicus Sprague Dawley testosterone 6-beta-hydroxylase, cytochrome P450/6-beta-A, (CYP3A2) | 1.45 ± 0.43 | 0.54 ± 0.30 | ↓ 2.7 | <0.0001 |
| AA892234 | ESTs, moderately similar to microsomal glutathione S-transferase 3 (H. sapiens) | 1.63 ± 0.20 | 0.61 ± 0.25 | ↓ 2.7 | <0.0001 |
| U10357 | Pyruvate dehydrogenase kinase 2 subunit p45 (PDK2) | 1.70 ± 0.34 | 0.64 ± 0.18 | ↓ 2.7 | <0.0001 |
| J05031 | Isovaleryl Coenzyme A dehydrogenase | 1.60 ± 0.20 | 0.61 ± 0.25 | ↓ 2.6 | <0.0001 |
| AF075382 | Cytokine inducible SH2-containing protein 2 | 2.95 ± 1.39 | 1.13 ± 0.69 | ↓ 2.6 | 0.00090 |
| M81183 | Rat insulin-like growth factor I gene, 3′ end of exon 6 | 1.90 ± 0.58 | 0.73 ± 0.35 | ↓ 2.6 | <0.0001 |
| D28560 | Ectonucleotide pyrophosphatase/phosphodiesterase 2 | 1.41 ± 0.35 | 0.54 ± 0.36 | ↓ 2.6 | <0.0001 |
| AB002584 | Beta-alanine-pyruvate aminotransferase | 1.90 ± 0.61 | 0.74 ± 0.26 | ↓ 2.6 | <0.0001 |
| AA946532 | ATP-binding cassette, subfamily D (ALD), member 3 | 1.74 ± 0.55 | 0.68 ± 0.17 | ↓ 2.5 | <0.0001 |
| H33491 | Phenylalkylamine Ca2+ antagonist (emopamil) binding protein | 1.67 ± 0.44 | 0.66 ± 0.19 | ↓ 2.5 | <0.0001 |
| AB008424 | Rat cytochrome P-450 IID3 mRNA, complete cds | 1.55 ± 0.25 | 0.61 ± 0.33 | ↓ 2.5 | <0.0001 |
| J02791 | Acyl-coenzyme A dehydrogenase, C-4 to C-12 straight-chain | 1.67 ± 0.32 | 0.66 ± 0.31 | ↓ 2.5 | <0.0001 |
| J03588 | Guanidinoacetate methyltransferase | 1.27 ± 0.24 | 0.50 ± 0.27 | ↓ 2.5 | <0.0001 |
| Z50144 | Kynurenine aminotransferase II | 1.65 ± 0.22 | 0.66 ± 0.41 | ↓ 2.5 | <0.0001 |
| AI172017 | Aldehyde dehydrogenase 2, mitochondrial | 1.72 ± 0.27 | 0.69 ± 0.20 | ↓ 2.5 | <0.0001 |
| Ml1670 | Catalase | 1.55 ± 0.63 | 0.62 ± 0.33 | ↓ 2.5 | 0.00035 |
| S48325 | RLM6; diabetes-inducible cytochrome P450RLM6 (rats, liver, mRNA Partial, 1093 nt) | 1.37 ± 0.24 | 0.55 ± 0.24 | ↓ 2.5 | <0.0001 |
| M23601 | Monoamine oxidase B | 1.67 ± 0.24 | 0.67 ± 0.32 | ↓ 2.5 | <0.0001 |
| D85035 | Dihydropyrimidine dehydrogenase | 1.61 ± 0.34 | 0.65 ± 0.27 | ↓ 2.5 | <0.0001 |
| L24207 | Cytochrome P450, subfamily IIIA, polypeptide 3 | 1.62 ± 0.48 | 0.66 ± 0.25 | ↓ 2.5 | <0.0001 |
| X06150 | Glycine methyltransferase | 1.61 ± 0.41 | 0.65 ± 0.38 | ↓ 2.5 | <0.0001 |
| J04591 | Dipeptidyl peptidase 4 | 1.50 ± 0.28 | 0.61 ± 0.21 | ↓ 2.5 | <0.0001 |
| D63704 | Dihydropyrimidinase | 1.57 ± 0.18 | 0.64 ± 0.36 | ↓ 2.4 | <0.0001 |
| AA892675 | ESTs, weakly similar to T20360 hypothetical protein D2030.9b—Caenorhabditis elegans (C. elegans) | 1.74 ± 0.35 | 0.72 ± 0.24 | ↓ 2.4 | <0.0001 |
| AA891733 | ESTs, normalized rat kidney, Bento Soares Rattus sp. cDNA clone RKIAG10 3-end, mRNA sequence | 1.68 ± 0.42 | 0.70 ± 0.18 | ↓ 2.4 | <0.0001 |
| S45663 | SC2=synaptic glycoprotein (rats, brain, mRNA, 1178 nt) | 1.47 ± 0.31 | 0.61 ± 0.23 | ↓ 2.4 | <0.0001 |
| AA893235 | ESTs, G0/G1 switch gene 2 (predicted) | 1.78 ± 0.72 | 0.75 ± 0.36 | ↓ 2.4 | 0.00037 |
| AA799771 | ESTs, normalized rat heart, Bento Soares Rattus sp. cDNA clone RHEAF15 3-end, mRNA sequence | 1.78 ± 0.47 | 0.75 ± 0.22 | ↓ 2.4 | <0.0001 |
| AI639418 | Thyroxine deiodinase, type I | 1.47 ± 0.27 | 0.63 ± 0.27 | ↓ 2.4 | <0.0001 |
| M26594 | Rattus norvegicus malic enzyme (MAL) gene, exon 14 and complete cds | 1.74 ± 1.25 | 0.75 ± 0.24 | ↓ 2.3 | 0.01885 |
| L14323 | Phospholipase C-betal | 1.58 ± 0.16 | 0.68 ± 0.26 | ↓ 2.3 | <0.0001 |
| U17697 | Cytochrom P450 Lanosterol 14 alpha-demethylase | 1.62 ± 0.62 | 0.71 ± 0.25 | ↓ 2.3 | 0.00028 |
| AI013861 | 3-Hydroxyisobutyrate dehydrogenase | 1.44 ± 0.25 | 0.63 ± 0.21 | ↓ 2.3 | <0.0001 |
| H33426 | ESTs, farnesyl diphosphate farnesyl transferase 1 | 1.67 ± 0.40 | 0.73 ± 0.20 | ↓ 2.3 | <0.0001 |
| AF080568 | Phosphate cytidylyltransferase 2, ethanolamine | 1.66 ± 0.34 | 0.73 ± 0.26 | ↓ 2.3 | <0.0001 |
| X56228 | Thiosulfate sulphurtransferase (rhodanese) | 1.35 ± 0.17 | 0.60 ± 0.31 | ↓ 2.3 | <0.0001 |
| M86235 | Rattus norvegicus mRNA for ketohexokinase | 1.35 ± 0.16 | 0.60 ± 0.18 | ↓ 2.3 | <0.0001 |
| M12337 | Phenylalanine hydroxylase | 1.57 ± 0.17 | 0.70 ± 0.23 | ↓ 2.2 | <0.0001 |
| AI229440 | Diaphorase (NADH) (cytochrome b-5 reductase) | 1.74 ± 0.37 | 0.78 ± 0.20 | ↓ 2.2 | <0.0001 |
| M60103 | Protein tyrosine phosphatase, receptor-type, F | 1.77 ± 0.38 | 0.80 ± 0.21 | ↓ 2.2 | <0.0001 |
| U94856 | Paraoxonase 1 | 1.33 ± 0.13 | 0.60 ± 0.27 | ↓ 2.2 | <0.0001 |
| AA799645 | FXYD domain-containing ion transport regulator 1 | 1.70 ± 0.37 | 0.78 ± 0.28 | ↓ 2.2 | <0.0001 |
| AA892832 | ESTs, ELOVL family member 5, elongation of long chain fatty acids (yeast) | 1.51 ± 0.31 | 0.69 ± 0.29 | ↓ 2.2 | <0.0001 |
| M27467 | Cytochrome oxidase subunit VIc | 1.66 ± 1.12 | 0.76 ± 0.23 | ↓ 2.2 | 0.01813 |
| M33648 | Rat mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase mRNA, complete cds | 1.35 ± 0.31 | 0.63 ± 0.19 | ↓ 2.2 | <0.0001 |
| H31897 | ESTs, rat PC-12 cells, untreated Rattus norvegicus cDNA clone RPCBC56 3- end, mRNA sequence | 1.48 ± 0.32 | 0.69 ± 0.27 | ↓ 2.1 | <0.0001 |
| J03914 | Glutathione S-transferase Yb subunit; rat glutathione S-transferase Yb subunit gene, complete cds | 1.43 ± 0.27 | 0.67 ± 0.22 | ↓ 2.1 | <0.0001 |
| K00996 | Cytochrome p-450e; rat cytochrome p-450e (phenobarbital-induced) mRNA, 3′ end | 1.58 ± 0.44 | 0.76 ± 0.21 | ↓ 2.1 | <0.0001 |
| AA875050 | ESTs, weakly similar to KICE RAT CHOLINE/ETHANOLAMINE KINASE (R. norvegicus) | 1.23 ± 0.14 | 0.60 ± 0.21 | ↓ 2.1 | <0.0001 |
| M89945 | Rat farnesyl diphosphate synthase gene, exons 1-8 | 1.33 ± 0.39 | 0.65 ± 0.30 | ↓ 2.1 | <0.0001 |
| L07736 | Carnitine palmitoyltransferase 1 alpha, liver isoform | 1.39 ± 0.42 | 0.68 ± 0.18 | ↓ 2.0 | <0.0001 |
| X12459 | Arginosuccinate synthetase 1 | 1.57 ± 0.22 | 0.78 ± 0.19 | ↓ 2.0 | <0.0001 |
| S83279 | HSD IV = peroxisome proliferator-inducible gene (rats, F344, liver, mRNA partial, 2480 nt) | 1.46 ± 0.30 | 0.73 ± 0.27 | ↓ 2.0 | <0.0001 |
| X64336 | Protein C | 1.36 ± 0.38 | 0.68 ± 0.22 | ↓ 2.0 | <0.0001 |
| M13100 | Rat long interspersed repetitive DNA sequence LINE3 (L1Rn) | 1.48 ± 0.60 | 0.74 ± 0.25 | ↓ 2.0 | 0.00151 |
| M15185 | S-adenosyl-l-homocysteine hydrolase (EC 3.3.1.1) | 1.41 ± 0.27 | 0.72 ± 0.20 | ↓ 2.0 | <0.0001 |
| AA859980 | T-complex 1 | 1.64 ± 0.52 | 0.84 ± 0.17 | ↓ 2.0 | 0.00020 |
| D13921 | Acetyl-Co A acetyltransferase 1, mitochondrial | 1.28 ± 0.23 | 0.65 ± 0.19 | ↓ 2.0 | <0.0001 |
| AB000199 | Rattus norvegicus cca2 mRNA, complete cds | 1.50 ± 0.48 | 0.77 ± 0.24 | ↓ 1.9 | 0.00023 |
| AA866302 | 4-Hydroxyphenylpyruvic acid dioxygenase | 1.46 ± 0.24 | 0.76 ± 0.22 | ↓ 1.9 | <0.0001 |
| X78855 | Organic cation transporter | 1.58 ± 0.38 | 0.82 ± 0.17 | ↓ 1.9 | <0.0001 |
| X16481 | Parathymosin | 1.41 ± 0.26 | 0.73 ± 0.18 | ↓ 1.9 | <0.0001 |
| AA892821 | Aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) | 1.32 ± 0.24 | 0.70 ± 0.18 | ↓ 1.9 | <0.0001 |
| X55660 | Proprotein convertase subtilisin/kexin type 3 | 1.49 ± 0.36 | 0.78 ± 0.13 | ↓ 1.9 | <0.0001 |
| AI639504 | ESTs, weakly similar to T13607 hypothetical protein EG: 87B1.3—fruit fly (D. melanogaster) | 1.40 ± 0.31 | 0.75 ± 0.24 | ↓ 1.9 | <0.0001 |
| AA799762 | ESTs, similar to RIKEN cDNA 2700038C09 (predicted) | 1.49 ± 0.24 | 0.80 ± 0.30 | ↓ 1.9 | <0.0001 |
| D85844 | Rabaptin 5 | 1.47 ± 0.14 | 0.80 ± 0.17 | ↓ 1.8 | <0.0001 |
| L12016 | Immature protein; rat tricarboxylate transport protein mRNA, complete cds | 1.55 ± 0.32 | 0.84 ± 0.14 | ↓ 1.8 | <0.0001 |
| AI639097 | rx01264s rat mixed-tissue library Rattus norvegicus cDNA clone rx01264 3′, mRNA sequence | 1.64 ± 0.59 | 0.89 ± 0.32 | ↓ 1.8 | 0.00122 |
| AA945583 | Hydroxysteroid (17-beta) dehydrogenase 10 | 1.31 ± 0.25 | 0.76 ± 0.15 | ↓ 1.7 | <0.0001 |
| AI639417 | ESTs, membrane targeting (tandem) C2 domain containing 1 | 1.50 ± 0.47 | 0.86 ± 0.30 | ↓ 1.7 | 0.00092 |
| X75253 | Phosphatidylethanolamine binding protein | 1.37 ± 0.16 | 0.80 ± 0.15 | ↓ 1.7 | <0.0001 |
| Upregulated genes | |||||
| M81855 | ATP-binding cassette, sub-family B (MDR/TAP), member 1 (P-glycoprotein/multidrug resistance 1) | 0.02 ± 0.01 | 1.62 ± 0.50 | ↑ 80.2 | <0.0001 |
| AI169327 | Tissue inhibitor of metalloproteinase 1 | 0.07 ± 0.04 | 2.65 ± 1.57 | ↑ 35.6 | 0.00014 |
| M14656 | Sialoprotein (osteopontin) | 0.12 ± 0.04 | 4.19 ± 3.26 | ↑ 34.8 | 0.00121 |
| AI169612 | Adipocyte lipid-binding protein | 0.07 ± 0.08 | 1.36 ± 0.50 | ↑ 19.1 | <0.0001 |
| J03627 | S-100 related protein, clone 42C | 0.16 ± 0.05 | 2.70 ± 1.86 | ↑ 17.2 | 0.00062 |
| AI071531 | Oxidized low density lipoprotein (lectin-like) receptor 1 | 0.22 ± 0.12 | 3.01 ± 1.52 | ↑ 13.9 | <0.0001 |
| X70871 | Cyclin Gl | 0.20 ± 0.08 | 2.28 ± 0.81 | ↑ 11.6 | <0.0001 |
| AI639107 | ESTs, similar to RIKEN cDNA C730007L20 gene (LOC364396), mRNA | 0.14 ± 0.07 | 1.47 ± 0.43 | ↑ 10.2 | <0.0001 |
| AI639488 | ESTs, highly similar to A42772 mdm2 protein-rat (R. norvegicus) | 0.26 ± 0.05 | 2.59 ± 1.11 | ↑ 10.0 | <0.0001 |
| M58404 | Thymosin, beta 10 | 0.18 ± 0.06 | 1.78 ± 0.88 | ↑ 9.6 | <0.0001 |
| M32062 | Fc receptor, IgG, low affinity III | 0.20 ± 0.07 | 1.90 ± 0.80 | ↑ 9.4 | <0.0001 |
| U49729 | Bcl2-associated X protein | 0.20 ± 0.10 | 1.90 ± 0.84 | ↑ 9.4 | <0.0001 |
| AI172064 | Beta-galactoside-binding lectin | 0.17 ± 0.06 | 1.61 ± 0.89 | ↑ 9.3 | 0.00016 |
| AB010635 | Carboxylesterase 2 (intestine, liver) | 0.17 ± 0.05 | 1.49 ± 0.34 | ↑ 8.8 | <0.0001 |
| AA892506 | Coronin, actin binding protein 1A | 0.28 ± 0.16 | 2.49 ± 1.84 | ↑ 8.7 | 0.00164 |
| AA819500 | ESTs, highly similar to AC12_HUMAN ACTIVATOR 1 37 KD SUBUNIT (H. sapiens) | 0.20 ± 0.19 | 1.77 ± 0.88 | ↑ 8.7 | <0.0001 |
| M63282 | Activating transcription factor 3 | 0.37 ± 0.11 | 3.19 ± 2.43 | ↑ 8.6 | 0.00204 |
| J02962 | Lectin, galactose binding, soluble 3 | 0.18 ± 0.05 | 1.51 ± 0.49 | ↑ 8.4 | <0.0001 |
| M60921 | B-cell translocation gene 2, anti-proliferative | 0.30 ± 0.15 | 2.46 ± 1.95 | ↑ 8.3 | 0.00265 |
| M35300 | Serine protease inhibitor, kanzal type 1/trypsin inhibitor-like protein, pancreatic | 0.40 ± 0.16 | 3.36 ± 1.06 | ↑ 8.3 | <0.0001 |
| X95986 | Monomer; R. norvegicus CBR gene | 0.22 ± 0.14 | 1.84 ± 0.88 | ↑ 8.3 | <0.0001 |
| AA892775 | Lysozyme | 0.17 ± 0.05 | 1.39 ± 0.33 | ↑ 8.2 | <0.0001 |
| X62952 | Vimentin | 0.19 ± 0.05 | 1.40 ± 0.35 | ↑ 7.4 | <0.0001 |
| AA893246 | ESTs, ATPase, H+ transporting, V1 subunit D | 0.29 ± 0.06 | 1.79 ± 0.81 | ↑ 6.2 | <0.0001 |
| U18729 | Cytochrome b558 alpha-subunit | 0.23 ± 0.11 | 1.37 ± 0.79 | ↑ 6.0 | 0.00038 |
| M57276 | Leukocyte antigen (Ox-44) | 0.30 ± 0.13 | 1.80 ± 0.56 | ↑ 5.9 | <0.0001 |
| AA859536 | ESTs, brain abundant, membrane attached signal protein 1 | 0.32 ± 0.09 | 1.78 ± 0.81 | ↑ 5.5 | <0.0001 |
| AI233219 | Pineal specific PG25 protein | 0.38 ± 0.26 | 2.04 ± 0.79 | ↑ 5.4 | <0.0001 |
| X61654 | CD63 antigen | 0.30 ± 0.09 | 1.53 ± 0.76 | ↑ 5.2 | 0.00015 |
| AI639029 | ESTs, similar to lung inducible neuralized-related C3HC4 RING finger protein | 0.45 ± 0.14 | 2.33 ± 1.36 | ↑ 5.2 | 0.00056 |
| AI169104 | ESTs, highly similar to PLATELET FACTOR 4 PRECURSOR (R. norvegicus) | 0.35 ± 0.16 | 1.82 ± 0.97 | ↑ 5.1 | 0.00028 |
| X62951 | Rattus norvegicus mRNA (pBUS19) with repetitive elements | 0.52 ± 0.19 | 2.61 ± 1.74 | ↑ 5.1 | 0.00151 |
| AF001898 | Aldehyde dehydrogenase 1, subfamily A1 | 0.24 ± 0.10 | 1.15 ± 0.47 | ↑ 4.8 | <0.0001 |
| U02320 | Rattus norvegicus clone ndf40 neu differentiation factor mRNA, partial cds | 0.42 ± 0.20 | 1.97 ± 0.58 | ↑ 4.7 | <0.0001 |
| J05122 | Benzodiazepin receptor (peripheral) | 0.44 ± 0.09 | 2.07 ± 1.01 | ↑ 4.7 | 0.00016 |
| AA894004 | ESTs, highly similar to CAPG MOUSE MACROPHAGE CAPPING PROTEIN (M. musculus) | 0.41 ± 0.10 | 1.82 ± 0.90 | ↑ 4.5 | 0.00019 |
| AI231821 | Leukemia-associated cytosolic phosphoprotein stathmin | 0.39 ± 0.10 | 1.71 ± 0.85 | ↑ 4.4 | 0.00021 |
| AJ009698 | Embigin | 0.38 ± 0.14 | 1.55 ± 0.52 | ↑ 4.1 | <0.0001 |
| AA900505 | rhoB gene | 0.53 ± 0.12 | 2.09 ± 0.66 | ↑ 3.9 | <0.0001 |
| AF023087 | NGFI-A; Rattus norvegicus nerve growth factor induced factor A mRNA, partial 3′UTR | 0.35 ± 0.16 | 1.39 ± 0.38 | ↑ 3.9 | <0.0001 |
| AA891527 | Four and a half LIM domains 2 | 0.33 ± 0.14 | 1.30 ± 0.38 | ↑ 3.9 | <0.0001 |
| X13044 | CD74 antigen (invariant polpypeptide of major histocompatibility class II antigen-associated) | 0.35 ± 0.10 | 1.36 ± 0.91 | ↑ 3.8 | 0.00271 |
| X52196 | Arachidonate 5-lipoxygenase activating protein | 0.41 ± 0.08 | 1.53 ± 0.56 | ↑ 3.8 | <0.0001 |
| D13122 | ATPase inhibitor (rat mitochondrial IF1 protein) | 0.40 ± 0.09 | 1.48 ± 0.43 | ↑ 3.7 | <0.0001 |
| M76704 | O 6 -methylguanine-DNA methyltranferase | 0.33 ± 0.07 | 1.20 ± 0.27 | ↑ 3.6 | <0.0001 |
| U25264 | Selenoprotein W muscle 1 | 0.40 ± 0.16 | 1.44 ± 0.54 | ↑ 3.6 | <0.0001 |
| AI171966 | Rattus norvegicus mRNA for RT1.Mb | 0.37 ± 0.09 | 1.27 ± 0.49 | ↑ 3.5 | <0.0001 |
| X14254 | Invariant chain (AA 1-280); rat mRNA for MHC class II-associated invariant chain | 0.41 ± 0.10 | 1.39 ± 1.12 | ↑ 3.4 | 0.01136 |
| AI008888 | Cystatin beta | 0.41 ± 0.12 | 1.36 ± 0.26 | ↑ 3.3 | <0.0001 |
| X13016 | Rat mRNA for MRC OX-45 surface antigen | 0.40 ± 0.11 | 1.32 ± 0.23 | ↑ 3.3 | <0.0001 |
| M12919 | Aldolase A, fructose-bisphosphate | 0.43 ± 0.10 | 1.41 ± 0.61 | ↑ 3.3 | 0.00015 |
| U49930 | Caspase 3, apoptosis related cysteine protease (ICE-like cysteine protease) | 0.58 ± 0.11 | 1.91 ± 0.74 | ↑ 3.3 | <0.0001 |
| M83678 | RAB13 | 0.48 ± 0.07 | 1.55 ± 0.78 | ↑ 3.3 | 0.00057 |
| AF083269 | Actin-related protein complex 1b | 0.39 ± 0.08 | 1.26 ± 0.30 | ↑ 3.3 | <0.0001 |
| X52815 | Cytoskeletal gamma-actin (AA 1-375); rat mRNA for cytoplasmic-gamma isoform of actin | 0.45 ± 0.08 | 1.44 ± 0.40 | ↑ 3.2 | <0.0001 |
| U17919 | Allograft inflammatory factor 1 | 0.37 ± 0.07 | 1.17 ± 0.38 | ↑ 3.2 | <0.0001 |
| AA799717 | ESTs, polymerase (RNA) II (DNA directed) polypeptide I (predicted) | 0.50 ± 0.13 | 1.57 ± 0.74 | ↑ 3.1 | 0.00039 |
| AF017437 | Integrin-associated protein | 0.55 ± 0.18 | 1.71 ± 0.72 | ↑ 3.1 | 0.00014 |
| X07944 | Rat ornithine decarboxylase gene (EC 4.1.1.17) | 0.57 ± 0.12 | 1.77 ± 0.76 | ↑ 3.1 | 0.00018 |
| AA875523 | ESTs, similar to myosin, light polypeptide 6, alkali, smooth muscle and non-muscle isoform 1 (Canis familiaris) | 0.42 ± 0.11 | 1.30 ± 0.53 | ↑ 3.1 | 0.00011 |
| M17412 | Growth and transformation-dependent protein | 0.55 ± 0.10 | 1.70 ± 0.83 | ↑ 3.1 | 0.00058 |
| K02815 | Butyrophilin-like 2 (MHC class II associated) | 0.49 ± 0.20 | 1.47 ± 1.25 | ↑ 3.0 | 0.02078 |
| AF065438 | Rattus norvegicus mama mRNA, complete cds | 0.43 ± 0.12 | 1.28 ± 0.48 | ↑ 3.0 | <0.0001 |
| AA892005 | ESTs, SCIRP10-related protein | 0.55 ± 0.10 | 1.59 ± 0.75 | ↑ 2.9 | 0.00058 |
| J00797 | Rat alpha-tubulin gene, exon 1 | 0.49 ± 0.16 | 1.42 ± 0.29 | ↑ 2.9 | <0.0001 |
| S57478 | This sequence comes from Figure 2; lipocortin I (rats, genomic, 361 nt, segment 13 of 13) | 0.44 ± 0.07 | 1.25 ± 0.41 | ↑ 2.9 | <0.0001 |
| X51707 | Ribosomal protein S19 (AA 1-145); rat mRNA for ribosomal protein S19 | 0.47 ± 0.16 | 1.36 ± 0.47 | ↑ 2.9 | <0.0001 |
| M60666 | Tropomyosin 1 (alpha) | 0.54 ± 0.17 | 1.54 ± 0.36 | ↑ 2.8 | <0.0001 |
| D10587 | Rattus sp. mRNA for 85kDa sialoglycoprotein (LGP85), complete cds | 0.57 ± 0.20 | 1.61 ± 0.55 | ↑ 2.8 | <0.0001 |
| U64030 | dUTPase | 0.47 ± 0.10 | 1.33 ± 0.27 | ↑ 2.8 | <0.0001 |
| M34253 | Interferon regulatory factor 1 | 0.60 ± 0.17 | 1.64 ± 0.75 | ↑ 2.7 | 0.00051 |
| X53517 | CD37 antigen | 0.51 ± 0.11 | 1.39 ± 0.72 | ↑ 2.7 | 0.00143 |
| AI233173 | Expressed in nonmetastatic cells 1, protein (NM23A) (nucleoside diphosphate kinase) | 0.59 ± 0.08 | 1.58 ± 0.54 | ↑ 2.7 | <0.0001 |
| X78949 | Prolyl 4-hydroxylase alpha subunit | 0.56 ± 0.21 | 1.49 ± 0.40 | ↑ 2.6 | <0.0001 |
| X89225 | Rattus norvegicus mRNA for protein linked to system l-like neutral amino acid transport activity | 0.68 ± 0.33 | 1.77 ± 0.69 | ↑ 2.6 | 0.00017 |
| M12156 | Heterogeneous nuclear ribonucleoprotein A1 | 0.56 ± 0.10 | 1.42 ± 0.27 | ↑ 2.5 | <0.0001 |
| AF052596 | Synaptosomal-associated protein, 23 kD | 0.53 ± 0.18 | 1.34 ± 0.29 | ↑ 2.5 | <0.0001 |
| AB003042 | Complement component 5, receptor 1 | 0.53 ± 0.13 | 1.32 ± 0.23 | ↑ 2.5 | <0.0001 |
| S72594 | Tissue inhibitor of metalloproteinase type 2, TIMP-2 | 0.50 ± 0.06 | 1.24 ± 0.22 | ↑ 2.5 | <0.0001 |
| X05566 | Rat mRNA for myosin regulatory light chain (RLC) | 0.54 ± 0.10 | 1.35 ± 0.41 | ↑ 2.5 | <0.0001 |
| AF020618 | Myeloid differentiation primary response gene 116 | 0.77 ± 0.12 | 1.91 ± 1.18 | ↑ 2.5 | 0.00667 |
| X65228 | Rattus norvegicus mRNA for ribosomal protein L23a | 0.54 ± 0.20 | 1.33 ± 0.44 | ↑ 2.5 | <0.0001 |
| AA859305 | Rattus norvegicus mRNA for tropomyosin isoform 6 | 0.52 ± 0.24 | 1.27 ± 0.31 | ↑ 2.4 | <0.0001 |
| AB015433 | Solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 | 0.69 ± 0.23 | 1.68 ± 0.63 | ↑ 2.4 | 0.00016 |
| L19699 | v-ral simian leukemia viral oncogene homolog B (ras related) | 0.58 ± 0.08 | 1.40 ± 0.26 | ↑ 2.4 | <0.0001 |
| M15474 | Striated-muscle alpha tropomyosin; Rat alpha-tropomyosin gene, exon 11 | 0.50 ± 0.18 | 1.21 ± 0.38 | ↑ 2.4 | <0.0001 |
| AA944397 | ESTs, moderately similar to HS9B RAT HEAT SHOCK PROTEIN HSP 90-BETA (R. norvegicus) | 0.52 ± 0.29 | 1.26 ± 0.44 | ↑ 2.4 | 0.00011 |
| X54617 | Rat RLC-A gene for myosin regulatory light chain, exon 4 | 0.52 ± 0.07 | 1.26 ± 0.26 | ↑ 2.4 | <0.0001 |
| AA892373 | Syntenin | 0.63 ± 0.11 | 1.51 ± 0.70 | ↑ 2.4 | 0.00117 |
| D17445 | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide | 0.54 ± 0.15 | 1.30 ± 0.38 | ↑ 2.4 | <0.0001 |
| AA893670 | ESTs, tumor protein D52 (predicted) | 0.67 ± 0.16 | 1.61 ± 0.52 | ↑ 2.4 | <0.0001 |
| X78327 | Ribosomal protein L13 | 0.59 ± 0.16 | 1.41 ± 0.52 | ↑ 2.4 | 0.00016 |
| Y12635 | ATPase, H+ transporting, lysosomal (vacuolar proton pump), beta 56/58 kDa, isoform 2 | 0.58 ± 0.18 | 1.36 ± 0.40 | ↑ 2.4 | <0.0001 |
| AI072634 | Rattus norvegicus cytokeratin-18 mRNA, partial cds | 0.71 ± 0.22 | 1.68 ± 0.53 | ↑ 2.4 | <0.0001 |
| L03201 | Cathepsin S | 0.46 ± 0.15 | 1.07 ± 0.36 | ↑ 2.3 | <0.0001 |
| AA860030 | Rattus norvegicus mRNA for class I beta-tubulin, complete cds | 0.58 ± 0.06 | 1.36 ± 0.46 | ↑ 2.3 | 0.00010 |
| M63983 | Hypoxanthine guanine phosphoribosyl transferase | 0.53 ± 0.13 | 1.24 ± 0.30 | ↑ 2.3 | <0.0001 |
| U60882 | Heterogeneous nuclear ribonucleoproteins methyltransferase-like 2 (S. cerevisiae) | 0.61 ± 0.20 | 1.41 ± 0.44 | ↑ 2.3 | <0.0001 |
| J02780 | Tropomyosin 4 | 0.54 ± 0.11 | 1.26 ± 0.19 | ↑ 2.3 | <0.0001 |
| M31038 | RT1 class Ib gene | 0.64 ± 0.33 | 1.48 ± 0.61 | ↑ 2.3 | 0.00068 |
| AA944856 | RAP1B, member of RAS oncogene family | 0.63 ± 0.12 | 1.44 ± 0.23 | ↑ 2.3 | <0.0001 |
| X76453 | HRAS like suppressor | 0.58 ± 0.27 | 1.32 ± 0.45 | ↑ 2.3 | 0.00011 |
| AA892851 | ESTs, protein tyrosine kinase 9 (predicted) | 0.61 ± 0.28 | 1.38 ± 0.69 | ↑ 2.3 | 0.00271 |
| AA892308 | ESTs, similar to hypothetical protein D11Ertd497e (predicted) | 0.66 ± 0.12 | 1.50 ± 0.53 | ↑ 2.3 | 0.00018 |
| AA893584 | ESTs, biogenesis of lysosome-related organelles complex-1, sub-unit 2 (predicted) | 0.65 ± 0.20 | 1.47 ± 0.50 | ↑ 2.2 | 0.00012 |
| AI009806 | Dynein, cytoplasmic, light chain 1 | 0.56 ± 0.08 | 1.26 ± 0.18 | ↑ 2.2 | <0.0001 |
| S82383 | TM-5; slow-twitch alpha TM/hTMnm homolog (rats, macrophages, mRNA partial, 1742 nt) | 0.52 ± 0.10 | 1.16 ± 0.21 | ↑ 2.2 | <0.0001 |
| U21871 | Rattus norvegicus outer mitochondrial membrane receptor rTOM20 mRNA, complete cds | 0.69 ± 0.20 | 1.52 ± 0.48 | ↑ 2.2 | <0.0001 |
| M37584 | H2A histone family, member Z | 0.57 ± 0.19 | 1.26 ± 0.32 | ↑ 2.2 | <0.0001 |
| AI235585 | Cathepsin D | 0.61 ± 0.24 | 1.33 ± 0.33 | ↑ 2.2 | <0.0001 |
| AI228738 | FK506-binding protein 1 (12kD) | 0.61 ± 0.13 | 1.32 ± 0.40 | ↑ 2.2 | <0.0001 |
| AA899253 | Myristoylated alanine-rich protein kinase C substrate | 0.56 ± 0.13 | 1.18 ± 0.36 | ↑ 2.1 | <0.0001 |
| D42116 | Rattus norvegicus mRNA for 5I2 antigen, clone 17, partial cds | 0.55 ± 0.11 | 1.15 ± 0.23 | ↑ 2.1 | <0.0001 |
| AI177096 | ESTs, highly similar to APT RAT ADENINE PHOSPHORIBOSYLTRANSFERASE (R. norvegicus) | 0.65 ± 0.09 | 1.36 ± 0.32 | ↑ 2.1 | <0.0001 |
| D84477 | Rattus norvegicus mRNA for RhoA, partial cds | 0.58 ± 0.21 | 1.20 ± 0.23 | ↑ 2.1 | <0.0001 |
| M12672 | GTP-binding protein (G-alpha-i2) | 0.58 ± 0.12 | 1.21 ± 0.28 | ↑ 2.1 | <0.0001 |
| AI169417 | Phosphoglycerate mutase 1 | 0.70 ± 0.21 | 1.43 ± 0.44 | ↑ 2.0 | 0.00011 |
| X78167 | Rattus norvegicus (Sprague Dawley) ribosomal protein L15 mRNA | 0.64 ± 0.12 | 1.29 ± 0.30 | ↑ 2.0 | <0.0001 |
| AI231292 | Cystatin C (cysteine proteinase inhibitor) | 0.58 ± 0.15 | 1.17 ± 0.28 | ↑ 2.0 | <0.0001 |
| AF052042 | Rattus norvegicus zinc finger protein Y1 (RLZF-Y) mRNA, complete cds | 0.61 ± 0.22 | 1.22 ± 0.28 | ↑ 2.0 | <0.0001 |
| AA799545 | ESTs, weakly similar to TCPA RAT T-COMPLEX PROTEIN 1, ALPHA SUBUNIT (R. norvegicus) | 0.74 ± 0.21 | 1.46 ± 0.46 | ↑ 2.0 | 0.00017 |
| AA892014 | HLA-B associated transcript 1A | 0.73 ± 0.20 | 1.44 ± 0.36 | ↑ 2.0 | <0.0001 |
| X58465 | Rat mRNA for ribosomal protein S5 | 0.64 ± 0.11 | 1.28 ± 0.22 | ↑ 2.0 | <0.0001 |
| AA799501 | NADH ubiquinone oxidoreductase subunit B13 | 0.72 ± 0.19 | 1.42 ± 0.40 | ↑ 2.0 | <0.0001 |
| AI169370 | Alpha-tubulin | 0.60 ± 0.14 | 1.19 ± 0.18 | ↑ 2.0 | <0.0001 |
| AF022083 | Guanine nucleotide-binding protein beta 1 | 0.71 ± 0.15 | 1.40 ± 0.29 | ↑ 2.0 | <0.0001 |
| U44948 | Cysteine-rich protein 2 | 0.75 ± 0.14 | 1.47 ± 0.21 | ↑ 2.0 | <0.0001 |
| AA942751 | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide | 0.65 ± 0.15 | 1.25 ± 0.23 | ↑ 1.9 | <0.0001 |
| X62322 | Granulin | 0.57 ± 0.23 | 1.08 ± 0.31 | ↑ 1.9 | 0.00020 |
| X02904 | Glutathione S-transferase, pi 2 | 0.67 ± 0.15 | 1.27 ± 0.33 | ↑ 1.9 | <0.0001 |
| AI639132 | ESTs, similar to RIKEN cDNA 6720467C03 (predicted) | 0.76 ± 0.16 | 1.41 ± 0.28 | ↑ 1.9 | <0.0001 |
| L38615 | Glutathione synthetase gene | 0.63 ± 0.13 | 1.15 ± 0.15 | ↑ 1.8 | <0.0001 |
| U13895 | Rattus norvegicus MSS1 protein (MSS1) mRNA, partial cds | 0.73 ± 0.22 | 1.33 ± 0.25 | ↑ 1.8 | <0.0001 |
| X14181 | Ribosomal protein L18a (AA 1-175); rat mRNA for ribosomal protein L18a | 0.72 ± 0.15 | 1.27 ± 0.27 | ↑ 1.8 | <0.0001 |
| AA944324 | ADP-ribosylation factor 6 | 0.69 ± 0.10 | 1.19 ± 0.14 | ↑ 1.7 | <0.0001 |
| AI178135 | Complement component 1, q subcomponent binding protein | 0.77 ± 0.18 | 1.26 ± 0.15 | ↑ 1.6 | <0.0001 |
Genes are ranked by fold change.
Significance was calculated using the t-test.