TABLE 4.
GENES WITH MOST SIGNIFICANT CHANGES IN EXPRESSION BETWEEN LOW AND HIGH SCORES OF NECROINFLAMMATION
| GenBank Accession No. | Description | Mean ± SD of Necroinflammatory Scores | p-Value | ||
|---|---|---|---|---|---|
| 0 | 1–3 | 4–6 | |||
| Downregulated genes | |||||
| U10357 | Pyruvate dehydrogenase kinase 2 | 1.70 ± 0.34 | 0.63 ± 0.20 | 0.64 ± 0.14 | <0.0001 |
| AA893235 | ESTs, moderate similarity to protein sp:P27469 (H. sapiens) G0S2_HUMAN putative lymphocyte G0/G1 switch protein 2 | 1.78 ± 0.72 | 0.80 ± 0.41 | 0.60 ± 0.09 | 0.001 |
| AA799771 | ESTs, EST189268 normalized rat heart, Bento Soares Rattus sp. cDNA clone RHEAF15 3-end, mRNA sequence | 1.78 ± 0.47 | 0.75 ± 0.25 | 0.75 ± 0.15 | <0.0001 |
| H31897 | ESTs, EST106437 Rat PC-12 cells, untreated Rattus norvegicus cDNA clone RPCBC56 3-end, mRNA sequence | 1.48 ± 0.32 | 0.71 ± 0.29 | 0.64 ± 0.23 | <0.0001 |
| AF080468 | Glucose-6-phosphatase, transport protein 1 | 1.62 ± 0.45 | 0.58 ± 0.30 | 0.56 ± 0.04 | <0.0001 |
| AA893552 | Kallistatin | 2.70 ± 0.52 | 0.65 ± 0.28 | 0.66 ± 0.27 | <0.0001 |
| M00002 | Apolipoprotein A-IV | 2.99 ± 1.34 | 0.80 ± 0.34 | 0.60 ± 0.17 | <0.0001 |
| H33491 | Phenylalkylamine Ca2+ antagonist (emopamil) binding protein | 1.67 ± 0.44 | 0.65 ± 0.20 | 0.67 ± 0.21 | <0.0001 |
| X78855 | Solute carrier family 22, member 1 | 1.58 ± 0.38 | 0.85 ± 0.19 | 0.74 ± 0.06 | <0.0001 |
| AI639417 | ESTs, membrane targeting (tandem) C2 domain containing 1 | 1.50 ± 0.47 | 0.93 ± 0.29 | 0.66 ± 0.23 | 0.002 |
| AB000199 | CCA2 protein | 1.50 ± 0.48 | 0.81 ± 0.23 | 0.65 ± 0.28 | 0.0006 |
| Upregulated genes | |||||
| M12156 | Heterogeneous nuclear ribonucleoprotein A1 | 0.56 ± 0.10 | 1.35 ± 0.29 | 1.60 ± 0.09 | <0.0001 |
| U64030 | Deoxyuridinetriphosphatase (dUTPase) | 0.47 ± 0.10 | 1.28 ± 0.24 | 1.46 ± 0.40 | <0.0001 |
| L38615 | Glutathione synthetase | 0.63 ± 0.13 | 1.14 ± 0.18 | 1.18 ± 0.07 | <0.0001 |
| AI169370 | ESTs, Rattus norvegicus similar to tubulin alpha-1 chain—Chinese hamster (LOC300217), mRNA | 0.60 ± 0.14 | 1.13 ± 0.17 | 1.37 ± 0.06 | <0.0001 |
| AI009806 | Dynein, cytoplasmic, light chain 1 | 0.56 ± 0.08 | 1.26 ± 0.20 | 1.23 ± 0.14 | <0.0001 |
| M12672 | GTP-binding protein (G-alpha-i2) | 0.58 ± 0.12 | 1.17 ± 0.31 | 1.31 ± 0.20 | <0.0001 |
| S72594 | Tissue inhibitor of metalloproteinase type 2, TIMP-2T | 0.50 ± 0.06 | 1.24 ± 0.24 | 1.23 ± 0.20 | <0.0001 |
| AB010635 | Carboxylesterase 2 (intestine, liver) | 0.17 ± 0.05 | 1.41 ± 0.29 | 1.73 ± 0.42 | <0.0001 |
| J02780 | Tropomyosin 4 | 0.54 ± 0.11 | 1.24 ± 0.19 | 1.29 ± 0.24 | <0.0001 |
| AI169104 | ESTs, weak similarity to protein sp:P02776 (H. sapiens) PLF4_HUMAN Platelet factor 4 precursor (PF-4) | 0.35 ± 0.16 | 1.86 ± 1.12 | 1.70 ± 0.45 | 0.0002 |
| AA944397 | Heat shock protein 86 | 0.52 ± 0.29 | 1.19 ± 0.37 | 1.47 ± 0.64 | 0.0003 |
| D17445 | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide | 0.54 ± 0.15 | 1.30 ± 0.44 | 1.29 ± 0.18 | <0.0001 |
| J00797 | Rat alpha-tubulin gene, exon 1 | 0.49 ± 0.16 | 1.31 ± 0.25 | 1.74 ± 0.11 | <0.0001 |
| U02320 | Neuregulin 1 | 0.42 ± 0.20 | 2.02 ± 0.68 | 1.81 ± 0.07 | <0.0001 |
| AA900505 | rhoB gene | 0.53 ± 0.12 | 2.10 ± 0.72 | 2.07 ± 0.55 | <0.0001 |
| AA891527 | Four and a half LIM domains 2 | 0.33 ± 0.14 | 1.18 ± 0.34 | 1.65 ± 0.30 | <0.0001 |
| X62952 | Vimentin | 0.19 ± 0.05 | 1.34 ± 0.36 | 1.57 ± 0.27 | <0.0001 |
| X78949 | Prolyl 4-hydroxylase alpha subunit | 0.56 ± 0.21 | 1.44 ± 0.44 | 1.65 ± 0.25 | <0.0001 |
| M81855 | P-glycoprotein/multidrug resistance 1 | 0.03 ± 0.01 | 1.59 ± 0.50 | 1.71 ± 0.56 | <0.0001 |
| AA860030 | Tubulin, beta 5 | 0.58 ± 0.06 | 1.16 ± 0.29 | 1.96 ± 0.33 | <0.0001 |
| X05566 | Myosin regulatory light chain | 0.54 ± 0.10 | 1.41 ± 0.45 | 1.17 ± 0.20 | <0.0001 |
| X02904 | Glutathione S-transferase, pi 2 | 0.67 ± 0.15 | 1.30 ± 0.35 | 1.17 ± 0.27 | <0.0001 |
| X13016 | CD48 antigen | 0.40 ± 0.11 | 1.31 ± 0.22 | 1.35 ± 0.28 | <0.0001 |
| S82383 | TM-5; slow-twitch alpha TM/hTMnm homolog (rats, macrophages, mRNA partial, 1742 nt) | 0.52 ± 0.10 | 1.18 ± 0.24 | 1.09 ± 0.13 | <0.0001 |
| AI233219 | Endothelial cell-specific molecule 1 | 0.38 ± 0.26 | 2.14 ± 0.85 | 1.75 ± 0.65 | <0.0001 |
| AA859536 | ESTs, brain abundant, membrane attached signal protein 1 | 0.32 ± 0.09 | 1.82 ± 0.87 | 1.65 ± 0.69 | <0.0001 |
| AI178135 | Complement component 1, q subcomponent binding protein | 0.77 ± 0.18 | 1.26 ± 0.15 | 1.24 ± 0.18 | <0.0001 |
| AA819500 | ESTs, moderate similarity to protein ref:NP_002907.1 (H. sapiens) replication factor C (activator 1) 4 (37 kD) | 0.20 ± 0.19 | 1.90 ± 0.98 | 1.41 ± 0.41 | <0.0001 |
| AI169612 | Fatty acid binding protein 4 | 0.07 ± 0.08 | 1.36 ± 0.56 | 1.38 ± 0.34 | <0.0001 |
| L19699 | v-ral simian leukemia viral oncogene homolog B | 0.58 ± 0.08 | 1.42 ± 0.30 | 1.36 ± 0.01 | <0.0001 |
| U17919 | Allograft inflammatory factor 1 | 0.37 ± 0.07 | 1.17 ± 0.43 | 1.16 ± 0.26 | <0.0001 |
| AF023087 | Early growth response 1 | 0.35 ± 0.16 | 1.34 ± 0.33 | 1.55 ± 0.55 | <0.0001 |
| X54617 | Rat RLC-A gene for myosin regulatory light chain, exon 4 | 0.52 ± 0.07 | 1.30 ± 0.27 | 1.11 ± 0.19 | <0.0001 |
Significance was calculated using least squares means of ANOVA.