Table 3.
Meta-analysis of simulated data
| Model | Method | Optimizer | Hetero | LOR | L | U | Length | OR |
|---|---|---|---|---|---|---|---|---|
| geneity | of CI | |||||||
| GLMM | FIM | 0.3106 | 1.5477 | 1.0513 | 2.0442 | 0.9929 | 4.700646 | |
| GLMM | RIM | 0.3021 | 1.5446 | 1.0548 | 2.0344 | 0.9796 | 4.686097 | |
| GLMM | NCHGN | “optim” | 1169.0647 | 35.6833 | 26.9652 | 44.4014 | 17.4362 | 3.14∗1015 |
| GLMM | NCHGN | “nlminb” | 0.3113 | 1.5472 | 1.0502 | 2.0442 | 0.994 | 4.698297 |
| GLMM | NCHGN | “bobyqa” | 0.3113 | 1.5472 | 1.0502 | 2.0442 | 0.994 | 4.698297 |
| GLMM | NCHGN | “newuoa” | 0.3113 | 1.5472 | 1.0502 | 2.0442 | 0.994 | 4.698297 |
| GLMM | NCHGN | “uobyqa” | 0.3113 | 1.5472 | 1.0502 | 2.0442 | 0.994 | 4.698297 |
| GLMM | ABNM | 0.0160 | 0.6177 | 0.4943 | 0.7411 | 0.2468 | 1.854657 | |
| FEM | 1.4540 | 1.3671 | 1.5409 | 0.1738 | 4.280201 | |||
| REM | DL | 0.3159 | 1.5469 | 1.0463 | 2.0474 | 1.0011 | 4.696887 | |
| REM | REML | 0.3921 | 1.5476 | 0.9916 | 2.1035 | 1.1119 | 4.700176 |
Estimates and confidence intervals (CIs) for the heterogeneity parameter τ2, for the overall log-odds-ratio (LOR) and for the overall odds ratios (OR); GLMM is the generalized linear mixed model, REM is the random-effects model and FEM is the fixed-effect model. L and U are the lower and upper limits of the respective 95% confidence intervals