Table 4.
Hazard ratios and 95% confidence intervals of CKD progression associated with cumulative average marijuana use and hard illicit drug use by subgroups
| Subgroups | Marijuana Use | Hard Illicit Drug Use | ||||
|---|---|---|---|---|---|---|
| HR (95% CI) | P Value | P Value for Interaction | HR (95% CI) | P Value | P Value for Interaction | |
| Sex | ||||||
| Men | 0.93 (0.79 to 1.08) | 0.34 | 0.76 | 1.42 (1.10 to 1.82) | <0.01 | 0.07 |
| Women | 0.96 (0.78 to 1.19) | 0.74 | 0.88 (0.56 to 1.39) | 0.59 | ||
| Race | ||||||
| White | 0.84 (0.67 to 1.06) | 0.14 | 0.24 | 1.23 (0.84 to 1.79) | 0.29 | 0.90 |
| Nonwhite | 0.99 (0.85 to 1.15) | 0.88 | 1.26 (0.97 to 1.65) | 0.09 | ||
| Age, yr | ||||||
| <65 | 0.94 (0.81 to 1.08) | 0.38 | 0.92 | 1.26 (1.00 to 1.58) | 0.05 | 0.65 |
| ≥65 | 0.92 (0.66 to 1.29) | 0.62 | 1.02 (0.42 to 2.46) | 0.96 | ||
| Baseline eGFR | ||||||
| <45 | 0.95 (0.82 to 1.10) | 0.53 | 0.76 | 1.28 (1.00 to 1.63) | 0.05 | 0.80 |
| ≥45 | 0.91 (0.70 to 1.18) | 0.48 | 1.19 (0.72 to 1.96) | 0.50 | ||
Hazard ratios compare persistent marijuana use throughout follow-up with no marijuana use and persistent hard illicit drug use (use of cocaine, heroin, or methamphetamine) throughout follow-up with no hard illicit drug use. Adjusted for age, sex, race/ethnicity, clinical site, education, eGFR, proteinuria, history of diabetes, body mass index, systolic BP, hemoglobin, use of nonsteroidal anti-inflammatory drugs, and current smoking. HR, hazard ratio; 95% CI, 95% confidence interval.