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. 2018 Jul 1;7(7):209–231. doi: 10.1089/wound.2017.0761

Figure 5.

Figure 5.

Biomaterial and molecular-based strategies to resolve chronic wounds principally focus on promoting reepithelialization, angiogenesis, progenitor cell recruitment, directing macrophage polarization, and inhibiting the migration of excess inflammatory cells. Current strategies are very diverse, either directly delivering cytokines and growth factors to the wound, or by using siRNAs, miRNAs, stem cells, and EVs to alter cytokine expression and production by cells in the wound bed. Material-based strategies are also being explored, particularly for their potential to direct macrophage polarization. Blue arrows indicate inhibition and red arrows indicate induction. EV, extracellular vesicle; siRNA, small interfering RNA.

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