Figure 6.
Therapeutic strategies for cutaneous wound regeneration that are targeting the immune system. Therapeutics for scar prevention should, in general, promote antifibrotic macrophage polarization, and prevent mast cell degranulation and inflammatory macrophage polarization/recruitment. Pending future studies confirming the role of Tregs in skin regeneration, therapeutics should also promote their recruitment. This is currently being done via delivery of cytokines, chemokines, other antifibrotic mediators, and stem cells, though delivering siRNA, miRNA, and EVs may also be promising. Biomaterials present a promising means of delivering antifibrotic modulators, and their properties can also encourage macrophage polarization. Black arrows indicate differentiation, blue arrows indicate inhibition, and red arrows indicate induction. M6P, mannose-6-phosphate.