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. 2018 Jul 1;7(7):209–231. doi: 10.1089/wound.2017.0761

Table 3.

Biomaterial-based immunomodulatory strategies to reduce scarring

Material Property Function References
Deliver stem cells Reduces neutrophil recruitment, prevents respiratory burst 169–172
Encourages antifibrotic macrophage polarization
Attenuates T cell proliferation, encourages TH2 transition
Deliver neonatal cells Attenuates inflammatory response 169,173
HA-based Reduces TGF-β1 secretion 113,169
Stiffness Softer gels encourage anti-inflammatory polarization and reduced inflammation 155
Surface topography 1–5 μm gratings encourage anti-inflammatory macrophage polarization and reduce inflammation 174
Chemical cross-linking Triggers chronic foreign body response (increases scarring) 89

HA, hyaluronic acid.

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