Figure 2.

Effects of genistein, morphine, and genistein plus morphine on the mean nitric oxide levels of 48 mice were equally divided into six groups. *Significant increase of nitric oxide in morphine group compared to saline group (38.00% ± 2.09% vs. 18.72% ± 4.40%, χ² = 20.404, P < 0.001). ^†,‡Significant decrease of genistein plus morphine-administrated groups compared to morphine group (25 mg/kg: 25.92% ± 2.30% vs. 38.00% ± 2.09%, χ² = 17.103, P < 0.0001; 50 mg/kg: 24.74% ± 4.10% vs. 38% ± 2.09%, χ² = 25.050, P = 0.001, respectively).