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. 2018 Jul 4;16:185. doi: 10.1186/s12967-018-1564-x

Fig. 1.

Fig. 1

Frequency of clinically relevant gene targets. Total number of druggable single nucleotide variants (SNVs) (dark grey), druggable amplifications (light grey) and hotspot mutations (black) identified across the CUP cases (total number of variants n = 26). BRAF, MET, KRAS and HRAS were the most common druggable SNVs; MYC was the most common druggable copy number variant (CNV) detected; and TP53 was the most common hotspot gene detected