Figure 1.

Biomarker analyses showing postdose changes in complement and double‐stranded DNA. The dotted lines show the estimated pretreatment (baseline) mean analyte level in the study population (n = 20). The shaded bands represent the 95% confidence intervals (95% CIs) for the baseline means. The x‐axis indicates the nominal time points in days. The y₁‐axis (left) is the analyte level, and the y₂‐axis (right) is the estimated study population mean analyte level as a percentage of baseline. All available clinical study samples were analyzed, typically resulting in 10 observations per time point per dose. For some time points, there are as few as 8 observations.