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. Author manuscript; available in PMC: 2018 Jul 5.
Published in final edited form as: Cell Rep. 2018 May 1;23(5):1553–1564. doi: 10.1016/j.celrep.2018.03.133

Figure 4. IDH1R132H Gliomas with Atrx Loss Display an ALT Phenotype.

Figure 4

Representative images of immuno-FISH on brain sections from N::TVA; Cdkn2alox/lox;Atrxlox/lox;Ptenlox/lox and N::TVA;Cdkn2alox/lox;Ptenlox/lox gliomas from mice injected with viruses containing PDGFA, Cre, and IDH1R132H. White arrows indicate the co-localization of ALT-associated promyelocytic leukemia-like bodies (red) with telomeres (green). Background nuclear DNA is stained with Hoechst 33342 (blue). Scale bar represents 10 μm.