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The combination of CVC and atRA significantly reduced the expression of marker genes for liver fibrosis, bile duct proliferation and bile acid synthesis in BDL rats. (A) liver mRNA expression of Col1a1, Tgf-β1 and Ck19; (B) liver mRNA expression of Cyp7a1, Fxr and Shp; and (C) liver α-Sma protein expression detected by Western blot. Data were normalized to the house keeper gene Gapdh and quantified using Image J software. * p<0.05, n=6-9.
