Table 1.

Biocatalytic conversions of substrates 1 a‐Br–1 b‐Br.

Entry	Enzyme	Substrate	Conv. [%][a]	Selectivity [red/c]
1	OPR3 WT	1 a‐Br	74	66:34
2	YqjM WT	1 a‐Br	>99	59:41
3	WT OPR3	1 a‐Cl	98	85:15
4	WT YqjM	1 a‐Cl	>99	83:17
5	WT OPR3	1 b‐Br	97	72:28
6	WT YqjM	1 b‐Br	>99	93:7
7	OPR3 Y190F	1 a‐Br	93	12:88
8	OPR3 Y190W	1 a‐Br	45	22:78
9	YqjM Y169F	1 a‐Br	>99	2:98
10	YqjM Y169W	1 a‐Br	3	50:50
11	OPR3 Y190F	1 a‐Cl	99	73:27
12	OPR3 Y190W	1 a‐Cl	85	82:18
13	YqjM Y169F	1 a‐Cl	>99	66:34
14	WT OPR3	1 b‐Br	97	72:28
15	OPR3 Y190F	1 b‐Br	97	14:86
16	OPR3 Y190W	1 b‐Br	85	16:84
17	WT YqjM	1 b‐Br	>99	93:7
18	YqjM Y169F	1 b‐Br	>99	2:98
19	YqjM Y169W	1 b‐Br	28	25:75

[a] Conversions were determined by GC‐FID analysis of the crude reaction mixture by using 1,2‐DME as an internal standard; red=reduction product; c=cyclization product; n.d.=not detected.