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. 2018 Apr 2;33(6):1105–1113. doi: 10.1002/jbmr.3397

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© 2018 The Authors. Journal of Bone and Mineral Research Published by Wiley Periodicals Inc.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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SOST^TG joints are protected from excessive osteophyte formation, while Sost^‐/‐ joints are protected from subchondral bone loss in injured joints. μCT representation of mouse injured joints at 6 and 16 weeks post‐injury. Darker regions in the injured scans depict ectopic bone nodules (A). Osteophyte volume (gray area in A) was quantified at 6, 12, and 16 weeks post‐injury and compared between genotypes (B). Subchondral trabecular bone volume to total volume ratio was quantified and analyzed between injured and uninjured joints at 6, 12, and 16 weeks post‐injury. Scale bar = 1 mm. *p < 0.05, **p < 0.01, ***p < 0.001.