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. 2018 Apr 2;33(6):1105–1113. doi: 10.1002/jbmr.3397

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© 2018 The Authors. Journal of Bone and Mineral Research Published by Wiley Periodicals Inc.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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SOST^TG and WT injured joints treated with recombinant Sost (rmSost) protein have reduced levels of activated MMPs post‐injury. MMPSense was administered IV 5 hours post‐injury; rmSost was delivered IA post‐injury, and mean fluorescence intensity was measured 3 days post‐injury as depicted in A. SOST^TG‐ and rmSost‐treated injured joints displayed significantly less fluorescence than Sost^‐/‐ or WT control joints (B). Representative ex vivo images of WT uninjured (C) and injured WT (D), Sost^‐/‐ (E), and SOST^TG (F). Injured joints show reduced fluorescence in SOST^TG (F). Similarly, rmSost‐treated injured joints (H) show less fluorescence than PBS controls (G). **p < 0.01, ***p < 0.001.